ChEMBL ligand: CHEMBL5075209
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/Replicase polyprotein 1ab in Severe acute respiratory syndrome-related coronavirus [ChEMBL: CHEMBL5118] [GtoPdb: 3125, 3139, 3206] [UniProtKB: P0C6X7] CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!
CoV 3C-like (main) protease in SARS-CoV-2 [GtoPdb: 3111] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/Replicase polyprotein 1ab in Severe acute respiratory syndrome-related coronavirus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5118] [GtoPdb: 3125, 3139, 3206] [UniProtKB: P0C6X7]
ChEMBL	Inhibition of SARS-CoV-1 MPro	B	6.05	pIC50	900	nM	IC50	J Med Chem (2023) 66: 3664-3702 [PMID:36857133]
ChEMBL	Inhibition of SARS-CoV-1 MPro	B	6.05	pIC50	900	nM	IC50	Eur J Med Chem (2023) 257: 115491-115491 [PMID:37244162]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of C-terminal 6-His-tagged recombinant SARS CoV 3CL protease expressed in Escherichia coli BL21-Gold DE3 cells by FRET assay	B	6.05	pIC50	900	nM	IC50	J Med Chem (2022) 65: 2716-2746 [PMID:33186044]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	6.05	pIC50	900	nM	IC50	J Med Chem (2023) 66: 3664-3702 [PMID:36857133]
ChEMBL	Inhibition of recombinant SARS-CoV-2 Main protease	B	6.17	pIC50	670	nM	IC50	J Med Chem (2021) 64: 3508-3545 [PMID:33764065]
ChEMBL	Inhibition of SARS-CoV-2 Main protease transfected in Escherichia coli BL21-Gold (DE3) using (Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate by FRET assay	B	6.17	pIC50	670	nM	IC50	J Med Chem (2022) 65: 12500-12534 [PMID:36169610]
ChEMBL	Inhibition of recombinant SARS-COV2 main protease	B	6.17	pIC50	670	nM	IC50	Eur J Med Chem (2021) 213: 113157-113157 [PMID:33486200]
ChEMBL	Inhibition of SARS CoV-2 Main protease using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 peptide as substrate by FRET assay	B	6.17	pIC50	670	nM	IC50	J Med Chem (2021) 64: 16922-16955 [PMID:34798775]
ChEMBL	Inhibition of SARS-CoV-2 3CL protease	B	6.17	pIC50	670	nM	IC50	RSC Med Chem (2023) 14: 9-21 [PMID:36760740]
ChEMBL	Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate by FRET analysis	B	6.17	pIC50	670	nM	IC50	Bioorg Med Chem Lett (2023) 86: 129238-129238 [PMID:36924946]
ChEMBL	Inhibition of SARS-CoV-2 Main protease by FRET assay	B	6.17	pIC50	670	nM	IC50	Eur J Med Chem (2023) 257: 115491-115491 [PMID:37244162]
ChEMBL	Inhibition of C-terminal 6-His-tagged recombinant SARS CoV-2 3CL protease expressed in Escherichia coli BL21-Gold DE3 cells by FRET assay	B	6.17	pIC50	670	nM	IC50	J Med Chem (2022) 65: 2716-2746 [PMID:33186044]
ChEMBL	Inhibition of recombinant SARS-COV2 main protease using DabcylKTSAVLQISGFRKM-E(Edans)-N1-as substrate by FRET assay	B	6.92	pIC50	120	nM	IC50	J Med Chem (2022) 65: 13328-13342 [PMID:36179320]
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
GtoPdb	-	-	6.53	pKi	293	nM	Ki	J Med Chem (2024) 67: 7048-7067 [PMID:38630165]
CoV 3C-like (main) protease in SARS-CoV-2 [GtoPdb: 3111]
GtoPdb	-	-	6.92	pIC50	120	nM	IC50	J Med Chem (2022) 65: 13328-13342 [PMID:36179320]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]