ChEMBL ligand: CHEMBL304784
calpain 1/Calpain 1 in Human [ChEMBL: CHEMBL2111357] [GtoPdb: 2336] [UniProtKB: P04632, P07384] Calpain 1 in Pig [ChEMBL: CHEMBL4062] [UniProtKB: P35750] There should be some charts here, you may need to enable JavaScript!
cathepsin B/Cathepsin B in Human [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
calpain 1/Calpain 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111357] [GtoPdb: 2336] [UniProtKB: P04632, P07384]
ChEMBL	Inhibitory activity against Calpain I	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 209-214 [PMID:9871656]
Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750]
ChEMBL	Inhibition of pig erythrocyte mu-calpain	B	6.72	pKi	190	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4806-4808 [PMID:18694642]
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL	Inhibition of human liver cathepsin B	B	6.82	pKi	150	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4806-4808 [PMID:18694642]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR-3 infected in erythrocytes assessed as reduction in parasitemia after 72 hrs by light microscopic analysis	F	6.19	pIC50	640	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1293-1296 [PMID:23357632]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	5.07	pIC50	8600	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	5.07	pIC50	8590.14	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
ChEMBL	Inhibition of C-terminal His-tagged SARS-CoV-2 BetaCoV/Wuhan/WIV04/2019 Main protease expressed in Escherichia coli using Dabcyl-KTSAVLQ/SGFRKME(Edans) as substrate by FRET assay	B	6.01	pIC50	970	nM	IC50	J Med Chem (2022) 65: 12500-12534 [PMID:36169610]
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
GtoPdb	-	-	10.19	pKi	0.06	nM	Ki	J Med Chem (2024) 67: 7048-7067 [PMID:38630165]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]