ChEMBL ligand: CHEMBL4785363
CREB binding lysine acetyltransferase in Human [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!
EP300 lysine acetyltransferase in Human [GtoPdb: 2735] [UniProtKB: Q09472] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CREB binding lysine acetyltransferase in Human [GtoPdb: 2734] [UniProtKB: Q92793]
GtoPdb	Binding affinity for recombinant hCBP bromodomain determined by isothermal titration calorimetry (ITC).	-	7.85	pKd	14	nM	Kd	J Med Chem (2022) 65: 785-810 [PMID:34962793]
GtoPdb	Binding affinity for hCBP bromodomain determined by surface plasmon resonance (SPR).	-	8.77	pKd	1.7	nM	Kd	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]
EP300 lysine acetyltransferase in Human [GtoPdb: 2735] [UniProtKB: Q09472]
GtoPdb	Binding affinity for human p300 bromodomain determined by surface plasmon resonance (SPR)	-	8.77	pKd	1.7	nM	Kd	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]
GtoPdb	Inhibition of histone binding determined in a cell-based BRET assay.	-	7.72	pIC50	19	nM	IC50	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]