S33084 [Ligand Id: 129] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL65280 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Ability to displace [125I]iodosulpiride from human dopamine D2 (hD2) receptor transfected into CHO cells. | B | 7.5 | pKi | 31.62 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 2059-2064 [PMID:10450981] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 6.69 | pKi | 205 | nM | Ki | Med Chem Res (2004) 13: 25-33 |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity for human Dopamine receptor D3 | B | 8.6 | pKi | 8.6 | nM | Log Ki | J Med Chem (2005) 48: 3663-3679 [PMID:15916415] |
| ChEMBL | Ability to displace [125I]iodosulpiride from human dopamine D3 (hD3) receptor transfected into CHO cells. | B | 9.5 | pKi | 0.32 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 2059-2064 [PMID:10450981] |
| GtoPdb | - | - | 9.6 | pKi | 0.25 | nM | Ki | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
| D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 8.62 | pKi | 2.42 | nM | Ki | Med Chem Res (2004) 13: 25-33 |
| 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
| 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
| 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 6 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
| 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
| 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| GtoPdb | - | - | 7.1 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
