metatinib [Ligand Id: 12614] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2143592 (Bms-794833) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Competitive inhibition of c-Met (unknown origin) in presence of ATP | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Inhibition of Ron (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt-3 (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Inhibition of Axl (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Competitive inhibition of VEGFR2 (unknown origin) in presence of ATP | B | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| GtoPdb | - | - | 7.65 | pKi | 22.4 | nM | Ki | Exp Mol Med (2022) 54: 1450-1460 [PMID:36056187] |
| GtoPdb | Inhibition at intracellular ATP concentration of 1 mM | - | 6.89 | pIC50 | 129.9 | nM | IC50 | Exp Mol Med (2022) 54: 1450-1460 [PMID:36056187] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
