ChEMBL ligand: CHEMBL3407552
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1 in Human [ChEMBL: CHEMBL1795087] [GtoPdb: 2428] [UniProtKB: O94782] There should be some charts here, you may need to enable JavaScript!
Ubiquitin carboxyl-terminal hydrolase 19 in Human [ChEMBL: CHEMBL4523156] [UniProtKB: O94966] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 papain-like protease	B	6.25	pIC50	560	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795087] [GtoPdb: 2428] [UniProtKB: O94782]
GtoPdb	-	-	6.26	pIC50	544	nM	IC50	Mol Cancer Ther (2013) 12: 2651-62 [PMID:24130053]
ChEMBL	Inhibition of USP1 (unknown origin) by Ub-AMC assay	B	6.26	pIC50	544	nM	IC50	J Med Chem (2015) 58: 1581-1595 [PMID:25364867]
Ubiquitin carboxyl-terminal hydrolase 19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523156] [UniProtKB: O94966]
ChEMBL	Inhibition of C-terminal 6-His tagged USP19 (unknown origin) (1 to 1290 residues) using Ub-Rh110MP as substrate by fluorescence based assay	B	6.26	pIC50	544	nM	IC50	Eur J Med Chem (2024) 266: 116161-116161 [PMID:38262120]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3]
GtoPdb	-	-	6.26	pIC50	544	nM	IC50	Mol Cancer Ther (2013) 12: 2651-62 [PMID:24130053]
ChEMBL	Inhibition of USP1/UAF1 complex (unknown origin)	B	6.26	pIC50	544	nM	IC50	Eur J Med Chem (2024) 275: 116568-116568 [PMID:38889606]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]