WNY0824 [Ligand Id: 12143] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4747491
  • bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • bromodomain containing 2 in Human [GtoPdb: 1944] [UniProtKB: P25440]
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  • bromodomain containing 3 in Human [GtoPdb: 2725] [UniProtKB: Q15059]
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  • bromodomain testis associated in Human [GtoPdb: 2729] [UniProtKB: Q58F21]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
GtoPdb - - 6.96 pIC50 109 nM IC50 Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
ChEMBL Inhibition of BRD4 (unknown origin) by alpha-screen assay B 7.66 pIC50 22 nM IC50 Eur J Med Chem (2020) 191: 112152-112152 [PMID:32088495]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of full length human PLK1 using casein as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric assay B 6.96 pIC50 109 nM IC50 Eur J Med Chem (2020) 191: 112152-112152 [PMID:32088495]
GtoPdb - - 7.66 pIC50 22 nM IC50 Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain containing 2 in Human [GtoPdb: 1944] [UniProtKB: P25440]
GtoPdb - - 6.39 pIC50 403 nM IC50 Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain containing 3 in Human [GtoPdb: 2725] [UniProtKB: Q15059]
GtoPdb - - 6.82 pIC50 151 nM IC50 Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain testis associated in Human [GtoPdb: 2729] [UniProtKB: Q58F21]
GtoPdb - - 6.51 pIC50 312 nM IC50 Eur J Med Chem (2020) 191: 112152 [PMID:32088495]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]