ChEMBL ligand: CHEMBL4747491
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 2 in Human [GtoPdb: 1944] [UniProtKB: P25440] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 3 in Human [GtoPdb: 2725] [UniProtKB: Q15059] There should be some charts here, you may need to enable JavaScript!
bromodomain testis associated in Human [GtoPdb: 2729] [UniProtKB: Q58F21] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
GtoPdb	-	-	6.96	pIC50	109	nM	IC50	Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
ChEMBL	Inhibition of BRD4 (unknown origin) by radiometric ATP-competitive kinase assay	B	6.96	pIC50	109.3	nM	IC50	J Med Chem (2021) 64: 2419-2435 [PMID:33616410]
ChEMBL	Inhibition of BRD4 (unknown origin) by alpha-screen assay	B	6.96	pIC50	109	nM	IC50	Eur J Med Chem (2022) 227: 113922-113922 [PMID:34700270]
ChEMBL	Inhibition of BRD4 (unknown origin) by alpha-screen assay	B	7.66	pIC50	22	nM	IC50	Eur J Med Chem (2020) 191: 112152-112152 [PMID:32088495]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of full length human PLK1 using casein as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric assay	B	6.96	pIC50	109	nM	IC50	Eur J Med Chem (2020) 191: 112152-112152 [PMID:32088495]
ChEMBL	Inhibition of PLK1 (unknown origin) by radiometric ATP-competitive kinase assay	B	7.65	pIC50	22.3	nM	IC50	J Med Chem (2021) 64: 2419-2435 [PMID:33616410]
ChEMBL	Inhibition of recombinant full length human PLK1 using casein as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation counting method	B	7.66	pIC50	22	nM	IC50	Eur J Med Chem (2022) 227: 113922-113922 [PMID:34700270]
GtoPdb	-	-	7.66	pIC50	22	nM	IC50	Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain containing 2 in Human [GtoPdb: 1944] [UniProtKB: P25440]
GtoPdb	-	-	6.39	pIC50	403	nM	IC50	Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain containing 3 in Human [GtoPdb: 2725] [UniProtKB: Q15059]
GtoPdb	-	-	6.82	pIC50	151	nM	IC50	Eur J Med Chem (2020) 191: 112152 [PMID:32088495]
bromodomain testis associated in Human [GtoPdb: 2729] [UniProtKB: Q58F21]
GtoPdb	-	-	6.51	pIC50	312	nM	IC50	Eur J Med Chem (2020) 191: 112152 [PMID:32088495]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]