zanzalintinib [Ligand Id: 12093] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| GtoPdb | Inhibition of substrate phosphorylation by human c-MET (residues R974-S1390 with A1209G and V1290L) in vitro | - | 8 | pIC50 | <10 | nM | IC50 | WO2019148044A1. Compounds for the treatment of kinase-dependent disorders (2019) |
| AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| GtoPdb | Inhibition of hAxl kinase (residues H473-A894 with Q764R) activity in vitro | - | 8 | pIC50 | <10 | nM | IC50 | WO2019148044A1. Compounds for the treatment of kinase-dependent disorders (2019) |
| MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| GtoPdb | Inhibition of substrate phosphorylation by hMER (residues R557-E882 with H628Q and R794A) in vitro | - | 8 | pIC50 | <10 | nM | IC50 | WO2019148044A1. Compounds for the treatment of kinase-dependent disorders (2019) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
