BI-167107 [Ligand Id: 12065] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL579394
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ1-AR - 9.22 pEC50 0.6 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286];
Cell Res (2021) 31: 569-579 [PMID:33093660]
ChEMBL Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation F 9.22 pEC50 0.6 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ2-AR - 10 pEC50 0.1 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286]
ChEMBL Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation F 10 pEC50 0.1 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]