ASP5878 [Ligand Id: 11934] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594428 (Asp 5878, Asp-5878, Asp5878, ASP-5878, ASP5878) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Inhibition of FGFR1 (unknown origin) in presence of ATP at Km concentration by mobility shift assay | B | 9.33 | pIC50 | 0.47 | nM | IC50 | Bioorg Med Chem (2022) 59: 116657-116657 [PMID:35219181] |
| ChEMBL | Inhibition of recombinant FGFR1 (unknown origin) by mobility assay | B | 9.33 | pIC50 | 0.47 | nM | IC50 | J Med Chem (2022) 65: 7595-7618 [PMID:35635004] |
| fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
| ChEMBL | Inhibition of FGFR2 (unknown origin) in presence of ATP at Km concentration by mobility shift assay | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem (2022) 59: 116657-116657 [PMID:35219181] |
| ChEMBL | Inhibition of recombinant FGFR2 (unknown origin) by mobility assay | B | 9.33 | pIC50 | 0.47 | nM | IC50 | J Med Chem (2022) 65: 7595-7618 [PMID:35635004] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Inhibition of FGFR3 (unknown origin) in presence of ATP at Km concentration by mobility shift assay | B | 8.46 | pIC50 | 3.5 | nM | IC50 | Bioorg Med Chem (2022) 59: 116657-116657 [PMID:35219181] |
| ChEMBL | Inhibition of wild type N-terminal GST tagged FGFR3 (436 to 806 residues) (unknown origin) expressed in sf21 insect cells preincubated for 30 mins followed by substrate addition and measured after 30 mins in presence of ATP by off-chip mobility shift assay | B | 8.68 | pIC50 | 2.1 | nM | IC50 | Bioorg Med Chem (2022) 59: 116657-116657 [PMID:35219181] |
| GtoPdb | - | - | 8.68 | pIC50 | 2.1 | nM | IC50 | Bioorg Med Chem (2022) 59: 116657 [PMID:35219181] |
| ChEMBL | Inhibition of recombinant FGFR3 (unknown origin) by mobility assay | B | 9.33 | pIC50 | 0.47 | nM | IC50 | J Med Chem (2022) 65: 7595-7618 [PMID:35635004] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Inhibition of recombinant FGFR4 (unknown origin) by mobility assay | B | 9.33 | pIC50 | 0.47 | nM | IC50 | J Med Chem (2022) 65: 7595-7618 [PMID:35635004] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
