ChEMBL ligand: CHEMBL92708 (Calpeptin)
calpain 1/Calpain 1 in Human [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384] There should be some charts here, you may need to enable JavaScript!
Calpain-9 in Human [ChEMBL: CHEMBL4523126] [UniProtKB: O14815] There should be some charts here, you may need to enable JavaScript!
cathepsin B/Cathepsin B in Human [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] There should be some charts here, you may need to enable JavaScript!
cathepsin K/Cathepsin K in Human [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] There should be some charts here, you may need to enable JavaScript!
cathepsin L/Cathepsin L in Human [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
CoV 3C-like (main) protease in SARS-CoV-2 [GtoPdb: 3111] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
calpain 1/Calpain 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384]
ChEMBL	The binding affinity against calpain.	B	8.15	pKi	7	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibitory activity against calpain.	B	6	pIC50	1000	nM	IC50	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of human erythrocytes mu-calpain using Pep1 as substrate incubated for 30 mins under shaking condition in presence of CaCl2 by fluorescence assay	B	6.53	pIC50	297	nM	IC50	Eur J Med Chem (2016) 121: 433-444 [PMID:27318120]
ChEMBL	Inhibition of calpain (unknown origin) using Suc-LY-AMC as fluorogenic substrate after 60 mins by spectrofluorometric analysis	B	7.28	pIC50	52	nM	IC50	Eur J Med Chem (2018) 157: 946-959 [PMID:30165342]
ChEMBL	Inhibitory activity against Calpain 1 in platelets.	B	7.4	pIC50	40	nM	IC50	J Med Chem (2000) 43: 305-341 [PMID:10669559]
GtoPdb	Inhibition of recombinant human calpain 1	-	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (1997) 7: 539-544
ChEMBL	Inhibitory activity evaluated against recombinant human calpain 1	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (1997) 7: 539-544
Calpain-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523126] [UniProtKB: O14815]
ChEMBL	Inhibition of human recombinant mini-CAPN9 pre-incubated for 10 mins before calpain FRET peptide 5-FAM /QXL520 substrate addition by FLIPR assay	B	5.55	pIC50	2840	nM	IC50	US-20180318405-A1. Targeting capn9/capns2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies (2018)
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL	Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated for 30 mins under shaking condition by fluorescence assay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2016) 121: 433-444 [PMID:27318120]
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235]
ChEMBL	Inhibitory activity against recombinant human cathepsin K	B	9.96	pIC50	0.11	nM	IC50	Bioorg Med Chem Lett (2004) 14: 275-278 [PMID:14684342]
ChEMBL	Inhibitory activity against human cathepsin K	B	9.96	pIC50	0.11	nM	IC50	Bioorg Med Chem Lett (2004) 14: 719-722 [PMID:14741275]
GtoPdb	-	-	9.96	pIC50	0.11	nM	IC50	Bioorg Med Chem Lett (2004) 14: 719-22 [PMID:14741275]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL	Inhibition of cathepsin L (unknown origin) using Z-FR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated for 30 mins under shaking condition by fluorescence assay	B	7.14	pIC50	72	nM	IC50	Eur J Med Chem (2016) 121: 433-444 [PMID:27318120]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Binding affinity to C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by Cheng-Prusoff equation analysis	B	5.91	pKd	1220	nM	Kd	Eur J Med Chem (2022) 244: 114857-114857 [PMID:36332548]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	4.97	pIC50	10690.55	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
ChEMBL	Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of Dabcyl-KTSAVLQ/SGFRKME(Edans) substrate and measured after 1 hr by FRET assay	B	4.97	pIC50	10690	nM	IC50	Bioorg Med Chem Lett (2021) 48: 128263-128263 [PMID:34271072]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	4.97	pIC50	10690	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
ChEMBL	Inhibition of SARS-CoV-2 3CLpro preincubated for 30 mins followed by addition of (Dabcyl)KTSAVLQSGFRKM(Glu) peptide substrate and measured after 1.5 hrs by FRET assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2021) 48: 128263-128263 [PMID:34271072]
ChEMBL	Inhibition of SARS-CoV-2 3CL (3264 to 3569 residues) preincubated for 30 mins followed by addition of Dabcyl-KTSAVLQSGFRKME(Edans) substrate and measured after 1 hr by flourescence based plate reader assay	B	5.32	pIC50	4810	nM	IC50	Bioorg Med Chem Lett (2021) 48: 128263-128263 [PMID:34271072]
ChEMBL	Inhibition of C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by FRET assay	B	5.61	pIC50	2430	nM	IC50	Eur J Med Chem (2022) 244: 114857-114857 [PMID:36332548]
CoV 3C-like (main) protease in SARS-CoV-2 [GtoPdb: 3111]
GtoPdb	-	-	4.97	pIC50	10690	nM	IC50	Cell Res (2020) 30: 678-692 [PMID:32541865]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]