ChEMBL ligand: CHEMBL1086110
phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1B/Phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
Phosphodiesterase 6A in Bovine [ChEMBL: CHEMBL3741] [UniProtKB: P11541] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7B/Phosphodiesterase 7B in Human [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
ChEMBL	Inhibition of PDE10A	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3738-3742 [PMID:21602043]
ChEMBL	Inhibition of PDE10A (unknown origin)	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem (2013) 21: 6053-6062 [PMID:23978358]
ChEMBL	Inhibition of recombinant human N-terminal His-tagged PDE10A2 expressed in HEK293 cells using cAMP as substrate measured after 60 mins	B	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (2019) 29: 406-412 [PMID:30587449]
ChEMBL	Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay	B	8.14	pIC50	7.3	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
ChEMBL	Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillation counting	B	8.14	pIC50	7.28	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
GtoPdb	-	-	8.14	pIC50	7.3	nM	IC50	J Med Chem (2011) 54: 7621-38 [PMID:21988093]
ChEMBL	Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counting	B	8.15	pIC50	7	nM	IC50	J Med Chem (2012) 55: 7299-7331 [PMID:22834877]
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL	Inhibition of PDE11A	B	6.11	pIC50	779	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay	B	6.16	pIC50	690	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL	Inhibition of PDE1B	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay	B	6.57	pIC50	270	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
ChEMBL	Inhibition of PDE2A	B	6.62	pIC50	239	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counting	B	6.62	pIC50	239	nM	IC50	J Med Chem (2012) 55: 7299-7331 [PMID:22834877]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL	Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
ChEMBL	Inhibition of PDE3A	B	5.43	pIC50	3700	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibition of PDE4A	B	5.3	pIC50	5000	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay	B	6.04	pIC50	920	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
ChEMBL	Inhibition of PDE5A	B	6.04	pIC50	919	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
Phosphodiesterase 6A in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3741] [UniProtKB: P11541]
ChEMBL	Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL	Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay	B	5.48	pIC50	3345	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 7B/Phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
ChEMBL	Inhibition of PDE7B	B	5.51	pIC50	3100	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL	Inhibition of PDE8A	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]
phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL	Inhibition of PDE9A	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2010) 53: 4399-4411 [PMID:20450197]
ChEMBL	Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2011) 54: 7621-7638 [PMID:21988093]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]