ChEMBL ligand: CHEMBL3775474
lysine demethylase 1A/LSD1/CoREST complex in Human [ChEMBL: CHEMBL3137262] [GtoPdb: 2669] [UniProtKB: O60341, Q9UKL0] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine demethylase 1A/LSD1/CoREST complex in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137262] [GtoPdb: 2669] [UniProtKB: O60341, Q9UKL0]
ChEMBL	Inhibition of recombinant human LSD1 (172 to 852 residues)/His-tagged human CoREST (286 to 482 residues) expressed in Escherichia coli BL21 (DE3) cells using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substrate assessed as increase in H3K4 methylation incubated for 40 mins	B	8.48	pIC50	3.3	nM	IC50	Eur J Med Chem (2022) 239: 114522-114522 [PMID:35749987]
GtoPdb	-	-	8.54	pIC50	2.9	nM	IC50	Sci Adv (2021) 7: [PMID:33712455]
lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341]
ChEMBL	Inhibition of GST-tagged human LSD1 (172 to 833 residues) expressed in Escherichia coli C43(DE3) pLysS using biotinylated histone H3 mono methylated K4 peptide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by time-resolved fluorescence assay	B	7	pIC50	<100	nM	IC50	ACS Med Chem Lett (2016) 7: 10-11 [PMID:26819657]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2022) 228: 114042-114042 [PMID:34915312]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (2023) 66: 71-94 [PMID:36537915]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2023) 254: 115367-115367 [PMID:37086699]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2022) 239: 114522-114522 [PMID:35749987]
ChEMBL	Irreversible inhibition of LSD1 (unknown origin)	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2022) 239: 114522-114522 [PMID:35749987]
GtoPdb	-	-	8.54	pIC50	2.9	nM	IC50	Sci Adv (2021) 7: [PMID:33712455]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]