ChEMBL ligand: CHEMBL15177 (L-660711, MK-571)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
Cysteinyl leukotriene receptor 1 in Guinea pig [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5] There should be some charts here, you may need to enable JavaScript!
ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] There should be some charts here, you may need to enable JavaScript!
ABCC4/Multidrug resistance-associated protein 4 in Human [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439] There should be some charts here, you may need to enable JavaScript!
ABCC5/Multidrug resistance-associated protein 5 in Human [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440] There should be some charts here, you may need to enable JavaScript!
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of human ABCG2 expressed in human SAOS-2 cells mediated mitoxantrone efflux using mitoxantrone as substrate by flow cytometry	B	4.3	pIC50	50000	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cells	F	4.58	pKi	26400	nM	Ki	Pharm Res (2002) 19: 773-779 [PMID:12134946]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells	F	4.88	pKi	13100	nM	Ki	Mol Pharmacol (1999) 56: 1219-1228 [PMID:10570049]
ChEMBL	Inhibition of human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles	B	5	pIC50	10000	nM	IC50	J Med Chem (2008) 51: 3275-3287 [PMID:18457386]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cells	F	5.4	pIC50	4000	nM	IC50	Kidney Int (2000) 57: 1636-1642 [PMID:10760098]
ChEMBL	Inhibition of ABCC2 overexpressed in MDCK cells at 100 uM by flow cytometric-based chloromethylfluorescein-diacetate accumulation assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (2009) 52: 1190-1197 [PMID:19170519]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells	F	5.58	pIC50	2620	nM	IC50	Mol Pharmacol (2001) 59: 1077-1085 [PMID:11306690]
Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
ChEMBL	Inhibition of Leukotriene D4 induced contraction of guinea-pig trachea was determined	F	8.8	pKd	1.58	nM	Kd	Bioorg Med Chem Lett (1992) 2: 1141-1146
ChEMBL	Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig trachea using [3H]LTD4	B	9	pKd	1	nM	Kd	J Med Chem (1990) 33: 1194-1200 [PMID:2157010]
ChEMBL	Compound was evaluated for its ability to displace [3H]LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranes	B	9.7	pKi	0.2	nM	Ki	J Med Chem (1991) 34: 1235-1242 [PMID:1849993]
ChEMBL	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	B	8.41	pIC50	3.9	nM	IC50	Bioorg Med Chem Lett (1992) 2: 1141-1146
ChEMBL	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (1992) 2: 1141-1146
ChEMBL	In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (1992) 35: 3832-3844 [PMID:1331447]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL	Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting	B	6.22	pKi	600	nM	Ki	J Med Chem (2009) 52: 4586-4595 [PMID:19580319]
ChEMBL	TP_TRANSPORTER: inhibition of GSSG uptake in membrane vesicle from MRP1-expressing HeLa cells	F	6.22	pKi	600	nM	Ki	Biochem J (1996) 314: 433-437 [PMID:8670053]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicle from MRP1-expressing HeLa cells	F	6.22	pKi	600	nM	Ki	Cancer Res (1996) 56: 988-994 [PMID:8640791]
ChEMBL	Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 25 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)	B	4.93	pIC50	11870	nM	IC50	J Nat Prod (2020) 83: 1461-1472 [PMID:32347726]
ChEMBL	Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 25000 nM after 72 hrs by CCK8 assay (Rvb = 38.54 +/- 5.62 nM)	B	5.28	pIC50	5220	nM	IC50	J Nat Prod (2016) 79: 2135-2142 [PMID:27504669]
ChEMBL	Inhibition of recombinant MRP1 expressed in human HeLa T5 cells assessed as ATP-dependent transport of [3H]para-aminohippurate	B	5.48	pIC50	3300	nM	IC50	J Med Chem (2009) 52: 4586-4595 [PMID:19580319]
ChEMBL	Inhibition of ABCC1 (unknown origin) overexpressing human KBV cells mediated efflux assessed as cisplatin IC50 using cisplatin as substrate at 25 uM	B	5.79	pIC50	1620	nM	IC50	J Med Chem (2023) 66: 8628-8642 [PMID:37332162]
ChEMBL	TP_TRANSPORTER: inhibition of Daunorubicin uptake (Daunorubicin: 0.6 uM) in membrane vesicles from GLC4/ADR cells	F	6.4	pIC50	400	nM	IC50	Br J Pharmacol (1999) 126: 681-688 [PMID:10188979]
ChEMBL	Inhibition of MRP1 in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in cell survival after 5 days by MTS assay	B	4.72	pEC50	19000	nM	EC50	J Med Chem (2018) 61: 9931-9951 [PMID:30351934]
ChEMBL	Modulation of MRP1 mediated drug efflux in doxorubicin-resistant human H69 cells assessed as accumulation of calcein AM incubated for 15 mins prior to calcein AM addition measured after 30 mins by fluorescence analysis	B	4.91	pEC50	12400	nM	EC50	Bioorg Med Chem (2014) 22: 5860-5870 [PMID:25311564]
ChEMBL	Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assay	B	5.55	pEC50	2850	nM	EC50	J Med Chem (2010) 53: 5467-5475 [PMID:20684594]
ABCC4/Multidrug resistance-associated protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
ChEMBL	TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cells	F	5	pIC50	10000	nM	IC50	Mol Pharmacol (2003) 63: 1094-1103 [PMID:12695538]
ABCC5/Multidrug resistance-associated protein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440]
ChEMBL	TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cells	F	4.4	pIC50	40000	nM	IC50	Mol Pharmacol (2003) 63: 1094-1103 [PMID:12695538]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb	Antagonism of [3H]LTD4 binding in COS-7 cells.	-	8	pIC50	10	nM	IC50	Nature (1999) 399: 789-93 [PMID:10391245]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]