lazertinib [Ligand Id: 10136] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | Measuring inhibition of mutant EGFR kinase activities in biochemical assays (equivalent potency against Del19, L858R, L858R/T790M and Del19/T790M EGFR mutants). NOTE lazertinib is inactive vs. wild type EGFR. | - | 7.7 | pIC50 | <20 | nM | IC50 | WO2016060443A2. Compounds and compositions for modulating EGFR mutant kinase activities. (2016) |
| kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | In a biochemical enzyme activity assay. | - | 6 | pIC50 | >1000 | nM | IC50 | WO2016060443A2. Compounds and compositions for modulating EGFR mutant kinase activities. (2016) |
| Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| GtoPdb | In a biochemical enzyme activity assay. | - | 7.7 | pIC50 | <20 | nM | IC50 | WO2016060443A2. Compounds and compositions for modulating EGFR mutant kinase activities. (2016) |
| spleen associated tyrosine kinase in Human [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| GtoPdb | In a biochemical enzyme activity assay. | - | 6.7 | pIC50 | 201 | nM | IC50 | WO2016060443A2. Compounds and compositions for modulating EGFR mutant kinase activities. (2016) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
