GNE-131 [Ligand Id: 10003] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| GtoPdb | IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. | - | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
| Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| GtoPdb | IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
| Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| GtoPdb | IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. | - | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
| Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| GtoPdb | IC50s were generated from pooled data generated on QPatch or Qube automated voltage-clamp platforms, with the membrane potential maintained at a voltage yielding full inactivation of the channel. | - | 7.04 | pIC50 | 92 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
| Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| GtoPdb | Value from radioligand binding assay; IC50 for displacement of [3H]GX-545. | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
| GtoPdb | IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2018) 61: 4810-4831 [PMID:29737846] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
