DNA glycosylases: Introduction

DNA glycosylases play a key role in repairing single base damage to DNA [3]; damage that can be caused by oxidation, alkylation, and deamination of DNA bases. These enzymes recognise and excise damaged bases and initiate accurate repair. DNA glycosylases are therefore crucial for maintaining genome integrity, but they also have recognised roles in processes that are associated with innate and adaptive immunity [1-2], the control of DNA methylation and epigenetic stability [4].


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1. Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra TK, Mitra S, Sur S, Brasier AR, Ba X, Boldogh I. (2014) Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway. J Immunol, 193 (9): 4643-53. [PMID:25267977]

2. Ba X, Bacsi A, Luo J, Aguilera-Aguirre L, Zeng X, Radak Z, Brasier AR, Boldogh I. (2014) 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. J Immunol, 192 (5): 2384-94. [PMID:24489103]

3. Jacobs AL, Schär P. (2012) DNA glycosylases: in DNA repair and beyond. Chromosoma, 121 (1): 1-20. [PMID:22048164]

4. Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos SA, Hazra TK, Hegde ML, Radak Z, Bacsi A, Brasier AR et al.. (2016) Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression. J Biol Chem, 291 (49): 25553-25566. [PMID:27756845]

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DNA glycosylases, introduction. Last modified on 16/01/2019. Accessed on 19/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/FamilyIntroductionForward?familyId=1020.