Compound class:
Synthetic organic
Comment: 1R-11 is a synthetic lipoxin mimetic that exhibits anti-inflammatory activities via a mechanism which appears to be mediated by agonism of the ALX/FPR2 G protein-coupled receptor [1].
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Bioactivity Comments |
Although 1R-11 has convincingly been shown to activate cellular calcium flux via Gαq-coupled ALX/FPR2 receptors (with maximal activation at 10 pM) an affinity value from a dose-response assay, or from a ligand-binding assay has not been reported [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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