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Plasmodium yoelii

Species ID:121
Name:Plasmodium yoelii
Associated with:1 targets
2 ligands
Description
P. yoelii (Py) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Py is used in rodent model studies of malaria, in particular the immune response and in vaccine development.

Interactions

Interactions
Key to terms and symbols Click column headers to sort
Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum lysine--tRNA ligase cladosporin Py - 7.4 pIC50 1
pIC50 7.4 (IC50 3.91x10-8 M) Sporozoite hepatocyte invasion assay [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Unknown MOA ganaplacide Py - 8.7 pIC50 2
pIC50 8.7 (IC50 2x10-9 M) Sporozoite hepatocyte invasion assay [2]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay

References

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1. Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S et al.. (2012) Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe, 11 (6): 654-63. [PMID:22704625]

2. Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A et al.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob. Agents Chemother., 58 (9): 5060-7. [PMID:24913172]