spirapril   Click here for help

GtoPdb Ligand ID: 6575

Synonyms: Renormax® | SCH-33844
Approved drug
spirapril is an approved drug (FDA (1994))
Compound class: Synthetic organic
Comment: ACE inhibitor prodrug metabolised to spiraprilat
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 146.54
Molecular weight 466.16
XLogP 2.97
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOC(=O)C(NC(C(=O)N1CC2(CC1C(=O)O)SCCS2)C)CCc1ccccc1
Isomeric SMILES CCOC(=O)[C@@H](N[C@H](C(=O)N1CC2(C[C@H]1C(=O)O)SCCS2)C)CCc1ccccc1
InChI InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1
InChI Key HRWCVUIFMSZDJS-SZMVWBNQSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. FDA (1994)
Withdrawn drug? Yes
Is prodrug? Yes
Active form spiraprilat
IUPAC Name Click here for help
(7S)-8-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-8-azaspiro[4.4]nonane-7-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
6006 spirapril
Synonyms Click here for help
Renormax® | SCH-33844
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9619016
Reactome Reaction Reactome logo R-HSA-9619024
Other databases
CAS Registry No. 83647-97-6 (source: PubChem)
ChEMBL Ligand CHEMBL431
DrugBank Ligand DB01348
DrugCentral Ligand 2474, 2474
GtoPdb PubChem SID 178103189
PubChem CID 5311447
Search Google for chemical match using the InChIKey HRWCVUIFMSZDJS-SZMVWBNQSA-N
Search Google for chemicals with the same backbone HRWCVUIFMSZDJS
Search PubMed clinical trials spirapril
Search PubMed titles spirapril
Search PubMed titles/abstracts spirapril
UniChem Compound Search for chemical match using the InChIKey HRWCVUIFMSZDJS-SZMVWBNQSA-N
UniChem Connectivity Search for chemical match using the InChIKey HRWCVUIFMSZDJS-SZMVWBNQSA-N
Wikipedia Spirapril