vanoxerine [Ligand Id: 9983] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL281594 (GBR 12909, GBR-12909, Vanoxerina, Vanoxerine) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation counting | B | 7.66 | pKi | 22 | nM | Ki | Bioorg Med Chem (2011) 19: 5756-5762 [PMID:21907583] |
| ChEMBL | Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 mins | B | 8.06 | pKi | 8.8 | nM | Ki | J Med Chem (2016) 59: 6329-6343 [PMID:27309376] |
| ChEMBL | Inhibition of [3H]dopamine reuptake at dopamine transporter | B | 8.29 | pKi | 5.07 | nM | Ki | J Med Chem (2009) 52: 5872-5879 [PMID:19791802] |
| ChEMBL | Displacement of [3H]-WIN35428 from human DAT expressed in HEK cell membrane assessed as inhibition constant by radioligand binding assay | B | 8.33 | pKi | 4.7 | nM | Ki | Bioorg Med Chem (2021) 51: 116509-116509 [PMID:34798381] |
| ChEMBL | Binding affinity towards dopamine transporter (DAT) by using [125I]RTI-55 radioligand | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2002) 45: 4371-4374 [PMID:12213078] |
| ChEMBL | Displacement of [125I]RTI55 from DAT | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2008) 51: 2795-2806 [PMID:18393401] |
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki |
Eur J Pharmacol (1989) 166: 493-504 [PMID:2530094]; Eur J Pharmacol (1984) 103: 241-8 [PMID:6237922]; J Pharmacol Exp Ther (1991) 258: 626-32 [PMID:1678014] |
| ChEMBL | Competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with human dopamine transporter | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2000) 43: 639-648 [PMID:10691690] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 6.72 | pIC50 | 190 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by microbeta liquid scintillation counting method | B | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem (2017) 25: 2266-2276 [PMID:28274674] |
| ChEMBL | Affinity was evaluated using [3H]WIN-35428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cells | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1998) 41: 3293-3297 [PMID:9703474] |
| ChEMBL | Inhibition of re-uptake of [3H]-DA at human DAT expressed in HEK293 cells by liquid scintillation counting | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2017) 25: 5278-5289 [PMID:28807575] |
| ChEMBL | Inhibition of human DAT | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
| ChEMBL | Affinity was evaluated using [3H]DA (radioligand) on Cloned human Dopamine transporter expressed in HEK cells | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (1998) 41: 3293-3297 [PMID:9703474] |
| ChEMBL | Inhibition of human dopamine transporter | B | 8.14 | pIC50 | 7.2 | nM | IC50 | Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743] |
| ChEMBL | The inhibition of reuptake against dopamine transporter | F | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2002) 45: 4371-4374 [PMID:12213078] |
| DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327] | ||||||||
| ChEMBL | Displacement of [3H]RTI-121 from mouse DAT in striatal membranes | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem (2015) 23: 222-230 [PMID:25468036] |
| DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
| ChEMBL | Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem (2010) 18: 640-649 [PMID:20036131] |
| ChEMBL | Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligand | B | 7.92 | pKi | 12.02 | nM | Ki | J Med Chem (2000) 43: 4151-4159 [PMID:11063611] |
| ChEMBL | Binding affinity at dopamine transporter from rat caudate-putamen tissue by [3H]WIN-35428 displacement. | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 629-632 [PMID:12639545] |
| ChEMBL | Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissue | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 2387-2390 [PMID:12161139] |
| ChEMBL | Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligand | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1999) 42: 4446-4455 [PMID:10543888] |
| ChEMBL | Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brain | B | 7.92 | pKi | 11.9 | nM | Ki | J Med Chem (2003) 46: 2589-2598 [PMID:12801223] |
| ChEMBL | Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamen | B | 7.92 | pKi | 11.9 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 3169-3173 [PMID:11720867] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamen | B | 7.94 | pKi | 11.6 | nM | Ki | J Med Chem (1994) 37: 2258-2261 [PMID:8057273] |
| ChEMBL | Affinity for rat dopamine transporter using [3H]WIN-35428 displacement. | B | 7.94 | pKi | 11.6 | nM | Ki | J Med Chem (1995) 38: 3933-3940 [PMID:7562926] |
| ChEMBL | Inhibition of DAT-mediated [3H]DA uptake in rat striatum | B | 7.97 | pKi | 10.6 | nM | Ki | J Med Chem (2006) 49: 4239-4247 [PMID:16821783] |
| ChEMBL | Inhibition of rat brain dopamine transporter as accumulation of [3H]DA | F | 7.97 | pKi | 10.6 | nM | Ki | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | Inhibition of [3H]dopamine uptake in DAT in rat striatum | B | 7.97 | pKi | 10.6 | nM | Ki | Bioorg Med Chem (2008) 16: 2769-2778 [PMID:18249549] |
| ChEMBL | Inhibitory constant towards reuptake of [125I]-13 from dopamine transporter in rat striatal membranes | B | 7.98 | pKi | 10.4 | nM | Ki | J Med Chem (1994) 37: 1535-1542 [PMID:8182712] |
| ChEMBL | Displacement of [3H]WIN-from DAT in rat striatum | B | 7.99 | pKi | 10.2 | nM | Ki | Bioorg Med Chem (2008) 16: 2769-2778 [PMID:18249549] |
| ChEMBL | Inhibition of [3H]WIN-35428 binding to rat striatum DAT | B | 8.07 | pKi | 8.56 | nM | Ki | J Med Chem (2006) 49: 4239-4247 [PMID:16821783] |
| ChEMBL | Inhibition of [3H]dopamine uptake via rat dopamine receptor. | B | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2003) 46: 1465-1469 [PMID:12672246] |
| ChEMBL | Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat. | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1999) 42: 5029-5042 [PMID:10585212] |
| ChEMBL | Binding affinity for dopamine transporter | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2002) 45: 1321-1329 [PMID:11882001] |
| ChEMBL | Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem (2007) 15: 1146-1159 [PMID:17127069] |
| ChEMBL | Affinity at rat dopamine transporter using [125I]RTI-55 displacement. | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2003) 46: 1465-1469 [PMID:12672246] |
| ChEMBL | Binding affinity against Dopamine transporter using [125]RTI-55 | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2001) 44: 3937-3945 [PMID:11689080] |
| ChEMBL | Binding affinity towards dopamine transporter (DAT) | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1385-1389 [PMID:12657288] |
| ChEMBL | Displacement of [3H]WIN-35428 from DAT in rat striatum membrane | B | 8.75 | pKi | 1.77 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5238-5241 [PMID:18774292] |
| ChEMBL | Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranes | B | 9.06 | pKi | 0.88 | nM | Ki | J Med Chem (1994) 37: 1535-1542 [PMID:8182712] |
| ChEMBL | In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]GBR-12395 displacement. | B | 10.22 | pKi | 0.06 | nM | Ki | J Med Chem (1996) 39: 543-548 [PMID:8558525] |
| ChEMBL | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum. | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Inhibition of [3H]cocaine binding to the dopamine transporter. | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Inhibition of [3H]WIN-35428 binding to the dopamine transporter. | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Inhibition of [3H]WIN-35065-2 binding to the dopamine transporter. | B | 7.62 | pIC50 | 24 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatum | B | 7.68 | pIC50 | 21.1 | nM | IC50 | J Med Chem (2004) 47: 6128-6136 [PMID:15566284] |
| ChEMBL | IC50 value was evaluated using [3H]WIN-35428 (radioligand) on Dopamine transporter in rat striatum. | B | 7.71 | pIC50 | 19.3 | nM | IC50 | J Med Chem (1998) 41: 3293-3297 [PMID:9703474] |
| ChEMBL | Inhibition of rat brain Dopamine transporter uptake as [3H]DA accumulation | F | 7.85 | pIC50 | 14.2 | nM | IC50 | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | Inhibitory activity against dopamine transporter (DAT) labeled with [3H]WIN-35428 in rat brain striatal membrane. | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (1998) 41: 699-705 [PMID:9513598] |
| ChEMBL | In vitro inhibition of [3H]WIN-35 428 binding to dopamine transporter on rat striatal membranes. | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (1997) 40: 35-43 [PMID:9016326] |
| ChEMBL | Inhibition of [3H]WIN-35428 binding to rat brain dopamine transporter | B | 7.97 | pIC50 | 10.6 | nM | IC50 | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | Inhibition of binding of 3[H] WIN-35 428 to Dopamine transporter (DAT) of rat striatum. | B | 7.97 | pIC50 | 10.6 | nM | IC50 | J Med Chem (2002) 45: 654-662 [PMID:11806716] |
| ChEMBL | Inhibition of binding of [3H]WIN-35 428 to (DAT) dopamine transporter in rat striatum | B | 7.97 | pIC50 | 10.6 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1591-1595 [PMID:12699762] |
| ChEMBL | Binding affinity towards dopamine transporter in rat striatum using [3H]WIN-35 428 as radioligand | B | 7.97 | pIC50 | 10.6 | nM | IC50 | J Med Chem (2003) 46: 1220-1228 [PMID:12646032] |
| ChEMBL | Binding affinity at the dopamine transporter in rast striatum by [3H]WIN-35428 displacement. | B | 7.97 | pIC50 | 10.6 | nM | IC50 | J Med Chem (2003) 46: 2205-2215 [PMID:12747792] |
| ChEMBL | In vitro binding affinity at dopamine transporter in rat striatum by [3H]WIN-35428 displacement. | B | 7.97 | pIC50 | 10.6 | nM | IC50 | J Med Chem (2001) 44: 937-948 [PMID:11300876] |
| ChEMBL | Reuptake inhibition of [3H]-labeled dopamine (DA) in rat. | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (1999) 42: 5029-5042 [PMID:10585212] |
| ChEMBL | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate. | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Inhibition of [3H]DA reuptake in rat caudate homogenate. | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2000) 43: 4840-4849 [PMID:11123994] |
| ChEMBL | Inhibition of uptake from dopamine transporter in rat striatum using [3H]DA as radioligand | F | 8.18 | pIC50 | 6.63 | nM | IC50 | J Med Chem (2003) 46: 1220-1228 [PMID:12646032] |
| ChEMBL | Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]CFT displacement. | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1996) 39: 749-756 [PMID:8576918] |
| ChEMBL | Binding against Dopamine transporter using radioligand as [3H]GBR 12935 | B | 8.26 | pIC50 | 5.5 | nM | IC50 | J Med Chem (1996) 39: 4704-4716 [PMID:8941383] |
| ChEMBL | Inhibition of dopamine DA reuptake | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (1996) 39: 4704-4716 [PMID:8941383] |
| ChEMBL | Compound was tested for its ability to inhibit the uptake of [3H]dopamine in DAT (dopamine transporter system) expressing cell line | F | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 261-266 [PMID:9871666] |
| ChEMBL | Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligand | B | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2559-2564 |
| ChEMBL | Inhibition of [3H]BTCP binding to the dopamine transporter. | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Binding affinity for rat Dopamine transporter. | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2000) 43: 4840-4849 [PMID:11123994] |
| ChEMBL | Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Inhibition of [3H]GBR-12935 binding to the dopamine transporter. | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditions | F | 8.58 | pIC50 | 2.63 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligand | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (1999) 42: 4446-4455 [PMID:10543888] |
| ChEMBL | Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]dopamine in nonstandard conditions on brain membranes obtained from rat | F | 8.76 | pIC50 | 1.75 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1992) 35: 969-981 [PMID:1552510] |
| ChEMBL | Displacement of [125I]RTI-55 dopamine transporter binding in rat striatal membrane | B | 9.37 | pIC50 | 0.43 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4915-4918 [PMID:16165350] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 5.84 | pIC50 | 1460 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells (PubChem AID: 1745860) | F | 6.1 | pIC50 | 790 | nM | IC50 | Sci Rep (2021) 11: 12290-null [PMID:34112854] |
| ChEMBL | Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2017) 25: 2266-2276 [PMID:28274674] |
| ChEMBL | Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2017) 25: 5278-5289 [PMID:28807575] |
| ChEMBL | Compound was tested for the inhibition of norepinephrine (NE) reuptake | F | 7.1 | pIC50 | 79 | nM | IC50 | J Med Chem (2002) 45: 4371-4374 [PMID:12213078] |
| Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
| ChEMBL | In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]nisoxetine displacement. | B | 4.7 | pKi | >20000 | nM | Ki | J Med Chem (1996) 39: 543-548 [PMID:8558525] |
| ChEMBL | Binding affinity at norepinephrine transporter using [3H]nisoxetine as radioligand from rat brain | B | 5.9 | pKi | 1270 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 3169-3173 [PMID:11720867] |
| ChEMBL | Displacement of [3H]nisoxetine from rat brain norepinephrine transporter | B | 5.9 | pKi | 1270 | nM | Ki | J Med Chem (2003) 46: 2589-2598 [PMID:12801223] |
| ChEMBL | The compound was tested for binding affinity nisoxatine ligand | B | 5.9 | pKi | 1270 | nM | Ki | J Med Chem (1999) 42: 4446-4455 [PMID:10543888] |
| ChEMBL | Inhibition of [3H]NE uptake in NET in rat cerebral cortex | B | 6.99 | pKi | 102 | nM | Ki | Bioorg Med Chem (2008) 16: 2769-2778 [PMID:18249549] |
| ChEMBL | Inhibition of rat brain Norepinephrine transporter as accumulation of [3H]-NE | F | 6.99 | pKi | 102 | nM | Ki | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | Inhibition of NET-mediated [3H]NE uptake in rat cerebral cortex | B | 6.99 | pKi | 102 | nM | Ki | J Med Chem (2006) 49: 4239-4247 [PMID:16821783] |
| ChEMBL | Inhibition of [3H]norepinephrine uptake at the rat norepinephrine transporter. | B | 7.1 | pKi | 79 | nM | Ki | J Med Chem (2003) 46: 1465-1469 [PMID:12672246] |
| ChEMBL | Binding affinity at the norepinephrine transporter in rat striatum by [3H]nisoxetine displacement. | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2003) 46: 2205-2215 [PMID:12747792] |
| ChEMBL | Inhibition of binding of [3H]nisoxetine to (NET) norepinephrine transporter in rat striatum | B | 6.3 | pIC50 | 496 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1591-1595 [PMID:12699762] |
| ChEMBL | Inhibition of binding of [3H]- nisoxatine to Norepinephrine transporter (NET) of rat cerebral cortex. | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2002) 45: 654-662 [PMID:11806716] |
| ChEMBL | Binding affinity towards norepinephrine transporter in rat striatum using [3H]nisoxetine as radioligand | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2003) 46: 1220-1228 [PMID:12646032] |
| ChEMBL | Affinity at norepinephrine transporter (NET) in rat striatum, using [3H]- nisoxatine as radioligand | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2001) 44: 937-948 [PMID:11300876] |
| ChEMBL | Inhibition of rat brain Norepinephrine transporter as accumulation of [3H]NE | F | 6.94 | pIC50 | 114 | nM | IC50 | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Displacement of [125I]RTI55 from SERT | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2008) 51: 2795-2806 [PMID:18393401] |
| ChEMBL | Binding affinity for serotonin transporter (SERT) using [125I]RTI-55 | B | 6.9 | pKi | 126 | nM | Ki | J Med Chem (2002) 45: 4371-4374 [PMID:12213078] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 5.42 | pIC50 | 3840 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Affinity was evaluated using [3H]citalopram (radioligand) on human serotonin transporter expressed in HEK cells | B | 6.13 | pIC50 | 741 | nM | IC50 | J Med Chem (1998) 41: 3293-3297 [PMID:9703474] |
| ChEMBL | The inhibition of reuptake against Serotonin transporter (5-HT) | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2002) 45: 4371-4374 [PMID:12213078] |
| SERT/Serotonin transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4642] [GtoPdb: 928] [UniProtKB: Q60857] | ||||||||
| ChEMBL | Displacement of [3H]paroxetine from mouse SERT in whole brain membrane | B | 7.62 | pKi | 24.1 | nM | Ki | Bioorg Med Chem (2015) 23: 222-230 [PMID:25468036] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Binding affinity for serotonin transporter | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2002) 45: 1321-1329 [PMID:11882001] |
| ChEMBL | Binding affinity against serotonin transporter using [125]RTI-55 | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2001) 44: 3937-3945 [PMID:11689080] |
| ChEMBL | Binding affinity against Serotonin transporter (SERT) labelled with [125I]RTI-55 in rat. | B | 6.9 | pKi | 126 | nM | Ki | J Med Chem (1999) 42: 5029-5042 [PMID:10585212] |
| ChEMBL | Displacement of [125I]RTI55 from SERT in rat brain synaptosomes | B | 6.9 | pKi | 126 | nM | Ki | Bioorg Med Chem (2007) 15: 1146-1159 [PMID:17127069] |
| ChEMBL | Binding affinity towards rat serotonin transporter (SERT) | B | 6.9 | pKi | 126 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1385-1389 [PMID:12657288] |
| ChEMBL | Affinity at rat serotonin transporter using [125I]RTI-55 displacement. | B | 6.9 | pKi | 126 | nM | Ki | J Med Chem (2003) 46: 1465-1469 [PMID:12672246] |
| ChEMBL | Binding affinity against serotonin transporter by displacement of [3H]citalopram in rat brain | B | 6.98 | pKi | 105 | nM | Ki | J Med Chem (2003) 46: 2589-2598 [PMID:12801223] |
| ChEMBL | Binding affinity at Serotonin transporter using [3H]citalopram as radioligand from rat brain | B | 6.98 | pKi | 105 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 3169-3173 [PMID:11720867] |
| ChEMBL | Displacement of [3H]citalopram from SERT in rat brain stem membrane | B | 6.98 | pKi | 104 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5238-5241 [PMID:18774292] |
| ChEMBL | Inhibition of rat brain Serotonin transporter as accumulation of [3H]5-HT | F | 7.04 | pKi | 91.1 | nM | Ki | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | Inhibition of SERT-mediated [3H]5-HT uptake in rat cerebral cortex | B | 7.04 | pKi | 91.1 | nM | Ki | J Med Chem (2006) 49: 4239-4247 [PMID:16821783] |
| ChEMBL | Inhibition of [3H]5HT uptake in SERT in rat cerebral cortex | B | 7.04 | pKi | 91.1 | nM | Ki | Bioorg Med Chem (2008) 16: 2769-2778 [PMID:18249549] |
| ChEMBL | Inhibition of [3H]5-HT uptake at the rat serotonin transporter. | B | 7.14 | pKi | 73 | nM | Ki | J Med Chem (2003) 46: 1465-1469 [PMID:12672246] |
| ChEMBL | In vitro binding affinity towards serotonin transporter in rat cerebral cortical homogenates by [3H]paroxetine displacement. | B | 7.28 | pKi | 52.8 | nM | Ki | J Med Chem (1996) 39: 543-548 [PMID:8558525] |
| ChEMBL | Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligand | B | 7.62 | pKi | 24.1 | nM | Ki | J Med Chem (1999) 42: 4446-4455 [PMID:10543888] |
| ChEMBL | In vitro binding affinity at serotonin transporter in rat striatum by [3H]- citalopram displacement. | B | 6.88 | pIC50 | 132 | nM | IC50 | J Med Chem (2001) 44: 937-948 [PMID:11300876] |
| ChEMBL | Inhibition of binding of [3H]- citalopram to Serotonin transporter (SERT) of rat cerebral cortex. | B | 6.88 | pIC50 | 132 | nM | IC50 | J Med Chem (2002) 45: 654-662 [PMID:11806716] |
| ChEMBL | Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatum | B | 6.88 | pIC50 | 132 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1591-1595 [PMID:12699762] |
| ChEMBL | Binding affinity at serotonin transporter in rat striatum by [3H]citalopram displacement. | B | 6.88 | pIC50 | 132 | nM | IC50 | J Med Chem (2003) 46: 2205-2215 [PMID:12747792] |
| ChEMBL | Binding affinity towards serotonin transporter in rat striatum using [3H]citalopram as radioligand | B | 6.88 | pIC50 | 132 | nM | IC50 | J Med Chem (2003) 46: 1220-1228 [PMID:12646032] |
| ChEMBL | Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55 | B | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | Binding affinity for rat 5-hydroxytryptamine transporter. | B | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (2000) 43: 4840-4849 [PMID:11123994] |
| ChEMBL | Inhibition of rat brain Serotonin transporter uptake as [3H]5-HT accumulation | B | 6.99 | pIC50 | 101.4 | nM | IC50 | J Med Chem (2005) 48: 4962-4971 [PMID:16033275] |
| ChEMBL | IC50 value was evaluated using [3H]citalopram (radioligand) on serotonin transporter in rat striatum. | B | 7.06 | pIC50 | 87 | nM | IC50 | J Med Chem (1998) 41: 3293-3297 [PMID:9703474] |
| ChEMBL | Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane. | B | 7.06 | pIC50 | 86.6 | nM | IC50 | J Med Chem (1998) 41: 699-705 [PMID:9513598] |
| ChEMBL | Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]citalopram displacement. | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (1996) 39: 749-756 [PMID:8576918] |
| ChEMBL | In vitro inhibition of [3H]citalopram binding to serotonin transporter on rat striatal membranes. | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (1997) 40: 35-43 [PMID:9016326] |
| ChEMBL | Reuptake inhibition of [3H]-5-HT (5-HT) in rat. | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1999) 42: 5029-5042 [PMID:10585212] |
| ChEMBL | Inhibition of [3H]5-HT reuptake at rat serotonin transporter | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1996) 39: 4704-4716 [PMID:8941383] |
| ChEMBL | Inhibitory activity against [3H]- 5-hydroxytryptamine reuptake in whole rat brain minus cerebellum | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2000) 43: 4840-4849 [PMID:11123994] |
| ChEMBL | Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligand | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2559-2564 |
| Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] | ||||||||
| ChEMBL | Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane | B | 7.29 | pKi | 50.8 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5238-5241 [PMID:18774292] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand | B | 6.5 | pKi | 318 | nM | Ki | J Med Chem (2003) 46: 2589-2598 [PMID:12801223] |
| ChEMBL | Sigma receptor binding was determined by labeling with radioligand [3H](+)-pentazocine on frozen membranes obtained from frozen guinea pig brain | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1997) 40: 705-716 [PMID:9057857] |
| ChEMBL | The compound was tested for affinity towards sigma-3 receptor | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1994) 37: 4109-4117 [PMID:7990111] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
| ChEMBL | Binding affinity of Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG ligand | B | 6.94 | pKi | 116 | nM | Ki | J Med Chem (1999) 42: 4446-4455 [PMID:10543888] |
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 | Life Sci (1990) 47: PL133-7 [PMID:1980329] |
| Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] | ||||||||
| ChEMBL | Displacement of [3H]nisoxetine from NET in rat frontal cortex membrane | B | 6.3 | pKi | 497 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5238-5241 [PMID:18774292] |
| Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 6.49 | pIC50 | 320 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| σ2 in Rat [GtoPdb: 2553] [UniProtKB: Q5U3Y7] | ||||||||
| GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 | Life Sci (1990) 47: PL133-7 [PMID:1980329] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
