cenisertib [Ligand Id: 9927] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1614709 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | In a biochemical homogeneous time-resolved fluorescence (HTRF) kinase assay with an ATP concentration of 1 mM. | - | 7.02 | pIC50 | 95 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4750-5 [PMID:22695126] |
| aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
| GtoPdb | In a biochemical homogeneous time-resolved fluorescence (HTRF) kinase assay with an ATP concentration of 1 mM. | - | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4750-5 [PMID:22695126] |
| GtoPdb | Measuring phosphorylation of AurB substrate histone H3 in A549 cells. | - | 8.15 | pIC50 | 7 | nM | IC50 | WO2005118544A2. Cycloalkyl substituted pyrimidinediamine compounds and their uses. (2005) |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
