pexmetinib [Ligand Id: 9917] activity data from GtoPdb

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  • mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
Created with Highcharts 10.3.3ValuesChart context menumitogen-activated protein kinase 14pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • mitogen-activated protein kinase 11 in Human [GtoPdb: 1500] [UniProtKB: Q15759]
Created with Highcharts 10.3.3ValuesChart context menumitogen-activated protein kinase 11pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362]
Created with Highcharts 10.3.3ValuesChart context menufibroblast growth factor receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
Created with Highcharts 10.3.3ValuesChart context menufms related receptor tyrosine kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916]
Created with Highcharts 10.3.3ValuesChart context menufms related receptor tyrosine kinase 4pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
Created with Highcharts 10.3.3ValuesChart context menuTEK receptor tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519]
Created with Highcharts 10.3.3ValuesChart context menuABL proto-oncogene 1, non-receptor tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • ABL proto-oncogene 2, non-receptor tyrosine kinase in Human [GtoPdb: 1924] [UniProtKB: P42684]
Created with Highcharts 10.3.3ValuesChart context menuABL proto-oncogene 2, non-receptor tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241]
Created with Highcharts 10.3.3ValuesChart context menuFYN proto-oncogene, Src family tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • HCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2032] [UniProtKB: P08631]
Created with Highcharts 10.3.3ValuesChart context menuHCK proto-oncogene, Src family tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
Created with Highcharts 10.3.3ValuesChart context menuLYN proto-oncogene, Src family tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • misshapen like kinase 1 in Human [GtoPdb: 2103] [UniProtKB: Q8N4C8]
Created with Highcharts 10.3.3ValuesChart context menumisshapen like kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb - - 7.46 pIC50 35 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
mitogen-activated protein kinase 11 in Human [GtoPdb: 1500] [UniProtKB: Q15759]
GtoPdb - - 7.59 pIC50 26 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362]
GtoPdb - - 7.55 pIC50 28 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
GtoPdb - - 7.33 pIC50 47 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916]
GtoPdb - - 7.38 pIC50 42 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
GtoPdb - - 9 pIC50 1 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519]
GtoPdb - - 8.4 pIC50 4 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
ABL proto-oncogene 2, non-receptor tyrosine kinase in Human [GtoPdb: 1924] [UniProtKB: P42684]
GtoPdb - - 8 pIC50 10 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241]
GtoPdb - - 7.39 pIC50 41 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
HCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2032] [UniProtKB: P08631]
GtoPdb - - 7.59 pIC50 26 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb - - 7.6 pIC50 25 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]
misshapen like kinase 1 in Human [GtoPdb: 2103] [UniProtKB: Q8N4C8]
GtoPdb - - 7.59 pIC50 26 nM IC50 Cancer Res (2016) 76: 4841-4849 [PMID:27287719]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.