GW274150 [Ligand Id: 9849] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL114551 (Gw-274150, GW274150) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| GtoPdb | - | - | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| ChEMBL | In vitro inhibition of human neuronal nitric oxide synthase. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
| ChEMBL | Inhibition of human nNOS expressed in insect SF9 cells after 1 hr | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 336-343 [PMID:18024030] |
| Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
| ChEMBL | In vitro inhibition of human endothelial nitric oxide synthase. | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
| GtoPdb | - | - | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Inhibition of human iNOS expressed in baculovirus infected Spodoptera frugiperda cell using L-arginine as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by oxyhaemoglobin assay | B | 5.66 | pIC50 | 2190 | nM | IC50 | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting | B | 5.85 | pIC50 | 1412.54 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4228-4232 [PMID:21684157] |
| ChEMBL | Inhibition of human inducible nitric oxide synthase | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 597-600 [PMID:10741561] |
| ChEMBL | Inhibition of human recombinant iNOS by microtiter plate assay | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3037-3040 [PMID:21482467] |
| ChEMBL | Inhibition of human iNOS expressed in human DLD1 cells after 1 hr | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 336-343 [PMID:18024030] |
| GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| ChEMBL | In vitro inhibition of human Inducible nitric oxide synthase. | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
