LUF5962 [Ligand Id: 9813] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL207824 (LUF-5962)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
Created with Highcharts 10.3.3ValuesChart context menuAdenosine A1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
Created with Highcharts 10.3.3ValuesChart context menuAdenosine A2a receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
Created with Highcharts 10.3.3ValuesChart context menuAdenosine A3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells B 9.54 pKi 0.29 nM Ki J Med Chem (2006) 49: 2861-2867 [PMID:16686529]
GtoPdb - - 7.13 pIC50 - - - Br J Pharmacol (2018) 175: 1719-1730 [PMID:29486053]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Displacement of [3H]ZM 241385 from human adenosine A2a receptor expressed in HEK293 cells B 7.26 pKi 55 nM Ki J Med Chem (2006) 49: 2861-2867 [PMID:16686529]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in HEK293 cells B 7.46 pKi 35 nM Ki J Med Chem (2006) 49: 2861-2867 [PMID:16686529]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]