lodoxamide [Ligand Id: 9743] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1201266 (Lodoxamida, Lodoxamide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
| ChEMBL | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (2017) 60: 362-372 [PMID:27976894] |
| ChEMBL | Agonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay | F | 7.39 | pEC50 | 41.1 | nM | EC50 | Bioorg Med Chem (2023) 96: 117511-117511 [PMID:37976806] |
| ChEMBL | Agonist activity at human GPR35 by beta-arrestin recruitment assay | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem (2023) 96: 117511-117511 [PMID:37976806] |
| GtoPdb | In an AP-TGF-α shedding assay using GPR35 expressing HEK293 cells. | - | 9 | pEC50 | 1 | nM | EC50 | Br J Pharmacol (2018) 175: 154-161 [PMID:29068046] |
| GPR35/G-protein coupled receptor 35 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2390813] [GtoPdb: 102] [UniProtKB: Q9ES90] | ||||||||
| ChEMBL | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay | F | 6.37 | pEC50 | 422 | nM | EC50 | Bioorg Med Chem (2023) 96: 117511-117511 [PMID:37976806] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
