compound III [PMID: 24045148] [Ligand Id: 9709] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL3770411 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
| GtoPdb | Vs. recombinant human mPGES-1. | - | 6.74 | pIC50 | 180 | nM | IC50 | WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011) |
| ChEMBL | Inhibition of human microsomal PGES1 using PGH2 as substrate incubated for 90 secs by MDA-TBA assay | B | 7.05 | pIC50 | 90 | nM | IC50 | Medchemcomm (2015) 6: 2081-2123 |
| GtoPdb | Vs. recombinant human mPGES-1. | - | 7.05 | pIC50 | 90 | nM | IC50 | Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148] |
| mPGES1 in Rat [GtoPdb: 1377] | ||||||||
| GtoPdb | Vs. recombinant rat mPGES-1. | - | 6.04 | pIC50 | 920 | nM | IC50 | WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011) |
| GtoPdb | Vs. recombinant rat mPGES-1. | - | 6.05 | pIC50 | 900 | nM | IC50 | Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
