ChEMBL ligand: CHEMBL1190711 (BAY-613606)
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
component of inhibitor of nuclear factor kappa B kinase complex in Human [GtoPdb: 1989] [UniProtKB: O15111] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase kinase 2 in Human [GtoPdb: 2086] [UniProtKB: Q12851] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of SYK	B	8.12	pKi	7.5	nM	Ki	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
GtoPdb	-	-	7.59	pIC50	25.5	nM	IC50	PLoS ONE (2012) 7: e41343 [PMID:22815993]
ChEMBL	Inhibition of SYK in human Ramos B cells assessed as reduction in Ca2+ release	B	7.09	pEC50	81	nM	EC50	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
ChEMBL	Inhibition of SYK in human U937 cells assessed as reduction FcgammaR-mediated superoxide production	B	7.28	pEC50	52	nM	EC50	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
ChEMBL	Inhibition of SYK in peripheral blood monocytes assessed as reduction FcgammaR-mediated superoxide production	B	7.92	pEC50	12	nM	EC50	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
component of inhibitor of nuclear factor kappa B kinase complex in Human [GtoPdb: 1989] [UniProtKB: O15111]
GtoPdb	-	-	7.35	pKi	45	nM	Ki	PLoS ONE (2016) 11: e0150339 [PMID:26930276]
mitogen-activated protein kinase kinase kinase kinase 2 in Human [GtoPdb: 2086] [UniProtKB: Q12851]
GtoPdb	-	-	7.95	pIC50	11.3	nM	IC50	PLoS ONE (2012) 7: e41343 [PMID:22815993]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]