ChEMBL ligand: CHEMBL1214998
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] There should be some charts here, you may need to enable JavaScript!
protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] There should be some charts here, you may need to enable JavaScript!
protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] There should be some charts here, you may need to enable JavaScript!
protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Inhibition of beta-1 adrenoceptor ( assessed as residual activity at 1 uM )	B	5.63	pIC50	2351	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL	Inhibition of PKCalpha by TR-FRET assay	B	6	pIC50	1000	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL	Inhibition of PKCdelta by TR-FRET assay	B	6.06	pIC50	881	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL	Inhibition of PKD1 assessed as HDAC5 neuclear export	B	7.49	pIC50	32	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]
ChEMBL	Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export	B	7.49	pIC50	32	nM	IC50	J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
GtoPdb	Measuring inhibition of synthetic substrate phosphorylation in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.	-	9.22	pIC50	0.6	nM	IC50	J Med Chem (2010) 53: 5400-21 [PMID:20684591]
ChEMBL	Inhibition of PKD1 by TR-FRET assay	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]
ChEMBL	Inhibition of PKD1 by TR-FRET assay	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL	Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2010) 53: 5400-5421 [PMID:20684591]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]