TCDD [Ligand Id: 9642] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL30327 (2,3,7,8-Tetrachloro-Dibenzo[1,4]Dioxine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869] | ||||||||
| ChEMBL | Affinity on cytosolic Aromatic hydrocarbon receptor (Ah) | B | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (1997) 40: 4360-4371 [PMID:9435905] |
| ChEMBL | Activation of human AhR expressed in Saccharomyces cerevisiae YCM3 coexpressing ARNT incubated for 18 hrs | B | 8.05 | pEC50 | 9 | nM | EC50 | Eur J Med Chem (2022) 244: 114845-114845 [PMID:36274276] |
| Aryl hydrocarbon receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6099] [GtoPdb: 2951] [UniProtKB: P30561] | ||||||||
| ChEMBL | Agonist activity at Ah receptor in genetically engineered mouse cells expressing firefly luciferase gene by CALUX transactivational assay | F | 10.52 | pEC50 | 0.03 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 6258-6263 [PMID:21958547] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) | B | 9.16 | pKi | 0.7 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) | B | 8.57 | pIC50 | 2.69 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
