AF-906 [Ligand Id: 9538] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL494161 (Ro-51)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9]
ChEMBL Antagonist activity against human P2X2/3 receptor expressed in CHOK1 cells assessed as inhibition of alpha,beta-meATP-induced calcium response incubated for 20 mins by Fluo-3AM dye based FLIPR assay F 8.1 pKi 7.94 nM Ki US-20080207655-A1. Diaminopyrimidines as P2X3 and P2X2/3 modulators (2008)
ChEMBL Antagonist activity at human P2X2/3 receptor B 7.35 pIC50 44.9 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]
ChEMBL Antagonist activity at human P2X2/3 receptor expressed in 1321n1c cells by FLIPR F 8.3 pIC50 5.01 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
GtoPdb - - 8.9 pIC50 - - - Neuropharmacology (2016) 104: 31-49 [PMID:26686393]
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity at P2X1 receptor up to 10 uM F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
ChEMBL Antagonist activity at human P2X1 receptor expressed in rat C6-BU-1 cells B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9]
ChEMBL Antagonist activity at P2X2 receptor up to 10 uM F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
ChEMBL Antagonist activity at human P2X2 receptor expressed in rat C6-BU-1 cells B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373]
ChEMBL Antagonist activity at human P2X3 receptor expressed in rat C6-BU-1 cells B 8.2 pIC50 6.3 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]
GtoPdb - - 8.9 pIC50 - - - Neuropharmacology (2016) 104: 31-49 [PMID:26686393]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL Antagonist activity against rat P2X3 receptor expressed in CHOK1 cells assessed as inhibition of alpha,beta-meATP-induced calcium response incubated for 20 mins by Fluo-3AM dye based FLIPR assay F 8.53 pKi 2.95 nM Ki US-20080207655-A1. Diaminopyrimidines as P2X3 and P2X2/3 modulators (2008)
ChEMBL Antagonist activity at rat P2X3 receptor expressed in CHO cells by FLIPR F 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571]
ChEMBL Antagonist activity at P2X4 receptor up to 10 uM F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
ChEMBL Antagonist activity at human P2X4 receptor expressed in rat C6-BU-1 cells B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]
P2X5/P2X purinoceptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4942] [GtoPdb: 482] [UniProtKB: Q93086]
ChEMBL Antagonist activity at P2X5 receptor up to 10 uM F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572]
ChEMBL Antagonist activity at P2X7 receptor up to 10 uM F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2009) 19: 1632-1635 [PMID:19231178]
ChEMBL Antagonist activity at human P2X7 receptor expressed in HEK293 cells B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2021) 37: 127833-127833 [PMID:33540044]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]