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ChEMBL ligand: CHEMBL22870 (L-732138) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
ChEMBL | Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava. | F | 8.4 | pKd | 3.98 | nM | Kd | Bioorg Med Chem Lett (1997) 7: 203-208 |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 6.87 | pKi | 134 | nM | Ki | J Med Chem (2007) 50: 2779-2786 [PMID:17516639] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 9.14 | pKi | 0.73 | nM | Ki | J Med Chem (2008) 51: 1369-1376 [PMID:18266313] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting | B | 9.14 | pKi | 0.73 | nM | Ki | J Med Chem (2008) 51: 6334-6347 [PMID:18821747] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane | B | 9.14 | pKi | 0.73 | nM | Ki | J Med Chem (2009) 52: 5164-5175 [PMID:20560643] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes | B | 9.14 | pKi | 0.73 | nM | Ki | Bioorg Med Chem (2009) 17: 7337-7343 [PMID:19762245] |
ChEMBL | Displacement of [3H]substance P frome human NK1 receptor | B | 9.14 | pKi | 0.73 | nM | Ki | J Med Chem (2010) 53: 5491-5501 [PMID:20617791] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 9.14 | pKi | 0.73 | nM | Ki | J Med Chem (2011) 54: 2029-2038 [PMID:21366266] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2007) 50: 2779-2786 [PMID:17516639] |
ChEMBL | Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1995) 38: 934-941 [PMID:7535362] |
ChEMBL | Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (1995) 38: 934-941 [PMID:7535362] |
ChEMBL | Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP. | B | 8.49 | pIC50 | 3.24 | nM | IC50 | J Med Chem (1998) 41: 3609-3623 [PMID:9733486] |
ChEMBL | Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement. | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (1995) 38: 923-933 [PMID:7699709] |
GtoPdb | Antagonism of [125]-substance P binding, to NK1 receptors expressed in CHO cells. | - | 8.64 | pIC50 | 2.3 | nM | IC50 | J Biol Chem (1994) 269: 6587-91 [PMID:7509807] |
ChEMBL | Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P. | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (1995) 38: 934-941 [PMID:7535362] |
ChEMBL | Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (1993) 36: 2044-2045 [PMID:8393115] |
ChEMBL | Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined | B | 8.8 | pIC50 | 1.6 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2259-2262 [PMID:9873524] |
ChEMBL | Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (1994) 37: 1269-1274 [PMID:7513763] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting | B | 8.8 | pIC50 | 1.58 | nM | IC50 | J Med Chem (2008) 51: 6334-6347 [PMID:18821747] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 8.8 | pIC50 | -8.8 | - | logIC50 | J Med Chem (2008) 51: 1369-1376 [PMID:18266313] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane | B | 8.83 | pIC50 | 1.48 | nM | IC50 | J Med Chem (2009) 52: 5164-5175 [PMID:20560643] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes | B | 8.83 | pIC50 | 1.48 | nM | IC50 | Bioorg Med Chem (2009) 17: 7337-7343 [PMID:19762245] |
ChEMBL | Displacement of [3H]substance P frome human NK1 receptor | B | 8.83 | pIC50 | 1.48 | nM | IC50 | J Med Chem (2010) 53: 5491-5501 [PMID:20617791] |
ChEMBL | Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells | B | 8.83 | pIC50 | 1.48 | nM | IC50 | J Med Chem (2011) 54: 2029-2038 [PMID:21366266] |
NK1 receptor/Neurokinin 1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4027] [GtoPdb: 360] [UniProtKB: P14600] | ||||||||
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes | B | 6.87 | pKi | 134 | nM | Ki | Bioorg Med Chem (2009) 17: 7337-7343 [PMID:19762245] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cells | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2008) 51: 1369-1376 [PMID:18266313] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2008) 51: 6334-6347 [PMID:18821747] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2009) 52: 5164-5175 [PMID:20560643] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cells | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2011) 54: 2029-2038 [PMID:21366266] |
GtoPdb | - | - | 6.34 | pIC50 | ~460 | nM | IC50 | J Biol Chem (1994) 269: 6587-91 [PMID:7509807] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2008) 51: 6334-6347 [PMID:18821747] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2009) 52: 5164-5175 [PMID:20560643] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes | B | 6.4 | pIC50 | 398.11 | nM | IC50 | Bioorg Med Chem (2009) 17: 7337-7343 [PMID:19762245] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cells | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2011) 54: 2029-2038 [PMID:21366266] |
ChEMBL | Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cells | B | 6.4 | pIC50 | -6.4 | - | logIC50 | J Med Chem (2008) 51: 1369-1376 [PMID:18266313] |
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
ChEMBL | Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2259-2262 [PMID:9873524] |
ChEMBL | Binding affinity to the NK2 receptor assayed by displacement of [125I]-Neurokinin A | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (1994) 37: 1269-1274 [PMID:7513763] |
Neurokinin 2 receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3433] [UniProtKB: P79218] | ||||||||
ChEMBL | Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery. | F | 5.2 | pKd | 6309.57 | nM | Kd | Bioorg Med Chem Lett (1997) 7: 203-208 |
NK2 receptor/Neurokinin 2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4554] [GtoPdb: 361] [UniProtKB: P16610] | ||||||||
ChEMBL | Displacement of [3H]substance P frome rat NK2 receptor | B | 6.87 | pKi | 134 | nM | Ki | J Med Chem (2010) 53: 5491-5501 [PMID:20617791] |
ChEMBL | Displacement of [3H]substance P frome rat NK2 receptor | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2010) 53: 5491-5501 [PMID:20617791] |
NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
ChEMBL | Affinity to NK3 receptors assayed by displacement of [125I]-Bolton-Hunter labeled eledoisin radioligand | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (1994) 37: 1269-1274 [PMID:7513763] |
NK3 receptor/Neurokinin 3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3154] [GtoPdb: 362] [UniProtKB: P16177] | ||||||||
ChEMBL | Antagonistic potency for NK-3 receptor was determined in vitro, using isolated rat portal vein. | F | 5.2 | pKd | 6309.57 | nM | Kd | Bioorg Med Chem Lett (1997) 7: 203-208 |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]