YD-3 [Ligand Id: 9458] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL125021 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAR1/Proteinase-activated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116] | ||||||||
| ChEMBL | Antagonist activity at PAR1 in PAR-1-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation assay | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4708-4713 [PMID:25176330] |
| ChEMBL | Inhibition of PAR1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 7690-7695 [PMID:27482618] |
| PAR4/Proteinase activated receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4691] [GtoPdb: 350] [UniProtKB: Q96RI0] | ||||||||
| ChEMBL | Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation assay | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4708-4713 [PMID:25176330] |
| ChEMBL | Antagonist activity PAR4 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2016) 59: 7690-7695 [PMID:27482618] |
| GtoPdb | Antagonism of PAR4-AP-stimulated human platelet aggregation. | - | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4708-13 [PMID:25176330] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
