ChEMBL ligand: CHEMBL2047943
TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL	Inhibition of Mps1 (unknown origin) incubated for 120 mins in presence of substrate/ATP by ADP-Glo assay	B	7.44	pIC50	36	nM	IC50	Eur J Med Chem (2023) 245: 114887-114887 [PMID:36370549]
ChEMBL	Inhibition of full-length Mps1 kinase (unknown origin)	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6829-6833 [PMID:24183538]
ChEMBL	Inhibition of Mps1	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4377-4385 [PMID:22632936]
GtoPdb	-	-	8.74	pIC50	1.8	nM	IC50	Mol Cancer Ther (2011) 10: 2267-75 [PMID:21980130]
ChEMBL	Inhibition of C-terminal tGFP-tagged full-length human MPS1 expressed in mammalian expression system using myelin basic protein as substrate in presence of ATP	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2023) 66: 16484-16514 [PMID:38095579]
ChEMBL	Inhibition of GST-fused full length human TTK compound pre-incubated for 15 mins prior ATP addition by MBP-based assay	B	8.74	pIC50	1.8	nM	IC50	Bioorg Med Chem (2014) 22: 4968-4997 [PMID:25043312]
ChEMBL	Inhibition of human MPS1 expressed in Escherichia coli	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2013) 56: 4343-4356 [PMID:23634759]
ChEMBL	Inhibition of MPS1 (519 to 808 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) after 18 hrs	B	8.74	pIC50	1.8	nM	IC50	Eur J Med Chem (2019) 175: 247-268 [PMID:31121430]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of Aur A	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4377-4385 [PMID:22632936]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aur B	B	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4377-4385 [PMID:22632936]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of PLK1	B	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4377-4385 [PMID:22632936]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]