ipragliflozin [Ligand Id: 9394] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2018096 (ASP-1941, Ipragliflozin, Ipragliflozina, Ipragliflozine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4979] [GtoPdb: 915] [UniProtKB: P13866] | ||||||||
| ChEMBL | Inhibition of human SGLT1 | B | 5.73 | pIC50 | 1876 | nM | IC50 | Eur J Med Chem (2019) 184: 111773-111773 [PMID:31630053] |
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing hSGLT1. | - | 5.73 | pIC50 | 1876 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
| ChEMBL | Inhibition of SGLT1 (unknown origin) | B | 5.72 | pEC50 | 1900 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| Sodium/glucose cotransporter 1 in Mouse [GtoPdb: 915] [UniProtKB: Q8C3K6] | ||||||||
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing mSGLT1. | - | 5.86 | pIC50 | 1380 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
| Sodium/glucose cotransporter 1 in Rat [GtoPdb: 915] [UniProtKB: P53790] | ||||||||
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing rSGLT1. | - | 5.93 | pIC50 | 1166 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
| Sodium/glucose cotransporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3884] [GtoPdb: 916] [UniProtKB: P31639] | ||||||||
| ChEMBL | Inhibition of SGLT2 (unknown origin) | B | 8.08 | pIC50 | 8.4 | nM | IC50 | Bioorg Med Chem (2018) 26: 3947-3952 [PMID:29954682] |
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing hSGLT2. | - | 8.13 | pIC50 | 7.38 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
| ChEMBL | Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation counting | B | 8.13 | pIC50 | 7.4 | nM | IC50 | Bioorg Med Chem (2012) 20: 3263-3279 [PMID:22507206] |
| ChEMBL | Inhibition of recombinant human full-length SGLT2 expressed in CHO cells assessed as decrease in [14C]-AMG uptake measured after 2 hrs by topcount scintillation counting method | B | 8.13 | pIC50 | 7.4 | nM | IC50 | Medchemcomm (2018) 9: 1273-1281 [PMID:30151080] |
| ChEMBL | Inhibition of human SGLT2 | B | 8.13 | pIC50 | 7.38 | nM | IC50 | Eur J Med Chem (2019) 184: 111773-111773 [PMID:31630053] |
| ChEMBL | Inhibition of SGLT2 (unknown origin) | B | 8.13 | pEC50 | 7.4 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| Sodium/glucose cotransporter 2 in Mouse [GtoPdb: 916] [UniProtKB: Q923I7] | ||||||||
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing mSGLT2. | - | 8.25 | pIC50 | 5.64 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
| Sodium/glucose cotransporter 2 in Rat [GtoPdb: 916] [UniProtKB: P53792] | ||||||||
| GtoPdb | Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing rSGLT2. | - | 8.2 | pIC50 | 6.37 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2012) 385: 423-36 [PMID:22139434] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
