ChEMBL ligand: CHEMBL177820 (4,5,6,7-Tetrabromobenzotriazole)
casein kinase 2, alpha 1 polypeptide subunit/casein kinase 2, beta polypeptide subunit/Casein kinase 2 in Rat [ChEMBL: CHEMBL3988629] [GtoPdb: 1549, 1551] [UniProtKB: P19139, P67874] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] There should be some charts here, you may need to enable JavaScript!
NS3 in Hepatitis C virus [ChEMBL: CHEMBL1293269] [UniProtKB: A3EZJ3] There should be some charts here, you may need to enable JavaScript!
Casein kinase 2 in Rat [GtoPdb: 1548] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, alpha 1 polypeptide subunit/casein kinase 2, beta polypeptide subunit/Casein kinase 2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3988629] [GtoPdb: 1549, 1551] [UniProtKB: P19139, P67874]
ChEMBL	Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in presence of [32p]-ATP	B	6.4	pKi	400	nM	Ki	J Med Chem (2023) 66: 2257-2281 [PMID:36745746]
ChEMBL	Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in presence of [32p]-ATP	B	5.8	pIC50	1600	nM	IC50	J Med Chem (2023) 66: 2257-2281 [PMID:36745746]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Competitive inhibition of human CK2 assessed as competitive with respect to ATP	B	5.57	pKi	2700	nM	Ki	Bioorg Med Chem (2014) 22: 4553-4565 [PMID:25131958]
ChEMBL	Inhibition of human CK2 assessed as residual activity by KinaseProfiler assay	B	5.91	pIC50	1240	nM	IC50	Bioorg Med Chem (2014) 22: 4553-4565 [PMID:25131958]
ChEMBL	Inhibition of CK2 (unknown origin) using E-peptide as substrate incubated for 10 mins prior to testing by capillary electrophoretic analysis	B	6	pIC50	1000	nM	IC50	US-20130225674-A1. Use of dibenzofuranone derivatives to inhibit kinases (2013)
ChEMBL	Inhibition of CK2 (unknown origin)	B	6.05	pIC50	900	nM	IC50	Eur J Med Chem (2015) 96: 396-404 [PMID:25912672]
ChEMBL	Inhibition of human recombinant CK2 expressed in Escherichia coli BL21(DE3) using RRRDDDSDDD as substrate after 15 mins by capillary electrophoretic analysis	B	7.22	pIC50	60	nM	IC50	Eur J Med Chem (2013) 65: 205-222 [PMID:23711832]
ChEMBL	Inhibition of human recombinant CK2a1/CK2b holoenzyme expressed in Escherichia coli BL21(DE3) pre-incubated for 10 mins before substrate addition by capillary electrophoresis based assay	B	7.22	pIC50	60	nM	IC50	J Med Chem (2015) 58: 265-277 [PMID:25272055]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL	Inhibitory constant against Zea mays CK2alpha	B	6.4	pKi	400	nM	Ki	Biochem J (2003) 374: 639-646 [PMID:12816539]
ChEMBL	Binding affinity to CK2alpha (unknown origin)	B	6.4	pKi	400	nM	Ki	Eur J Med Chem (2014) 84: 364-374 [PMID:25036794]
ChEMBL	Inhibition of CK2alpha in human PLC1 cells using (Arg)3(Glu)3Thr(Glu)3 as substrate after 24 hrs in presence of [32P]gammaGTP	B	6.52	pKi	300	nM	Ki	Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
ChEMBL	Inhibition of recombinant full length human His-tagged CK2alpha1 expressed in baculovirus expression system using ser/thr-11 peptide as substrate measured after 1 hr by Z'-Lyte assay	B	5.83	pIC50	1480	nM	IC50	Medchemcomm (2018) 9: 1472-1490 [PMID:30288222]
ChEMBL	Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3)	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2920-2923 [PMID:19414254]
ChEMBL	Inhibition of human recombinant casein kinase 2 subunit alpha expressed in Escherichia coli BL21 (DE3) assessed as [32P] incorporation by liquid scintillation counting	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2009) 17: 1573-1578 [PMID:19168362]
ChEMBL	Inhibition of Zea mays CK2alpha	B	6.3	pIC50	500	nM	IC50	Biochem J (2003) 374: 639-646 [PMID:12816539]
ChEMBL	Inhibition of human CK2alpha using RRRDDDSDDD peptide substrate by P81 filter-binding assay	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2014) 84: 364-374 [PMID:25036794]
casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400]
ChEMBL	Binding affinity to recombinant human CK2alpha/beta expressed in Escherichia coli by surface plasmon resonance analysis	B	6.1	pKd	790	nM	Kd	Bioorg Med Chem (2018) 26: 3953-3957 [PMID:29934219]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL	Inhibition of DYRK1A (unknown origin)	B	5.36	pIC50	4360	nM	IC50	J Med Chem (2018) 61: 9791-9810 [PMID:29985601]
ChEMBL	Inhibition of DYRK1a	B	6	pIC50	<1000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
NS3 in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293269] [UniProtKB: A3EZJ3]
ChEMBL	Inhibitory concentration against hepatitis C virus helicase	B	4.7	pIC50	20000	nM	IC50	J Med Chem (2005) 48: 1-20 [PMID:15633995]
Casein kinase 2 in Rat [GtoPdb: 1548]
GtoPdb	-	-	6.4	pKi	400	nM	Ki	Biochem J (2003) 374: 639-46 [PMID:12816539]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]