MELK-TI [Ligand Id: 9366] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3355059 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
| ChEMBL | Inhibition of MELK kinase (unknown origin) using KKLNRTLSFAEPG/gamma[33P]ATP by Millipore kinase/scintillation counting analysis | B | 4.64 | pIC50 | 23000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| ChEMBL | Inhibition of MELK (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127202-127202 [PMID:32331933] |
| ChEMBL | Inhibition of MELK kinase (unknown origin) using biotinylated ZIP-tide peptide/gamma[33P]ATP by scintillation counting analysis | B | 7.43 | pIC50 | 37 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| ChEMBL | Inhibition of MELK (unknown origin) | B | 7.43 | pIC50 | 37 | nM | IC50 | ACS Med Chem Lett (2015) 6: 31-36 [PMID:25589926] |
| GtoPdb | Measured in a MIllipore kinase screening assay | - | 7.64 | pIC50 | 23 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt3 (unknown origin) by Millipore kinase analysis | B | 4.74 | pIC50 | 18000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| GtoPdb | Measured in a MIllipore kinase screening panel assay | - | 7.74 | pIC50 | 18 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| calcium/calmodulin-dependent protein kinase II delta subunit in Human [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
| GtoPdb | Measured in a MIllipore kinase screening panel assay | - | 6.09 | pIC50 | 810 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| GtoPdb | Measured in a MIllipore kinase screening assay | - | 6.12 | pIC50 | 760 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
