CHIR-124 [Ligand Id: 9365] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL377312 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| GtoPdb | - | - | 9.49 | pIC50 | 0.32 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3121-4 [PMID:16603354] |
| ChEMBL | Inhibition of CHK1 | B | 9.49 | pIC50 | 0.32 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3121-3124 [PMID:16603354] |
| ChEMBL | Inhibition of Chk1 (unknown origin) expressed in Sf9 insect cells using biotinylated cdc25c peptide as substrate in presence of 33P-gamma-labeled ATP by radioactive method | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Eur J Med Chem (2022) 236: 114304-114304 [PMID:35413618] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
