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ChEMBL ligand: CHEMBL375312 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
GtoPdb | - | - | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
ChEMBL | Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
ChEMBL | Inhibition of p70S6K | B | 5.71 | pIC50 | 1940 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
ChEMBL | Inhibition of RSK1 | B | 6.11 | pIC50 | 780 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
GtoPdb | - | - | 6.11 | pIC50 | 780 | nM | IC50 | J Med Chem (2007) 50: 6-9 [PMID:17201405] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]