VER-246608 [Ligand Id: 9350] activity data from GtoPdb

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  • pyruvate dehydrogenase kinase 2 in Human [GtoPdb: 2142] [UniProtKB: Q15119]
Created with Highcharts 10.3.3ValuesChart context menupyruvate dehydrogenase kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • pyruvate dehydrogenase kinase 3 in Human [GtoPdb: 2143] [UniProtKB: Q15120]
Created with Highcharts 10.3.3ValuesChart context menupyruvate dehydrogenase kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • pyruvate dehydrogenase kinase 4 in Human [GtoPdb: 2144] [UniProtKB: Q16654]
Created with Highcharts 10.3.3ValuesChart context menupyruvate dehydrogenase kinase 4pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • pyruvate dehydrogenase kinase 1 in Human [GtoPdb: 2915] [UniProtKB: Q15118]
Created with Highcharts 10.3.3ValuesChart context menupyruvate dehydrogenase kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
pyruvate dehydrogenase kinase 2 in Human [GtoPdb: 2142] [UniProtKB: Q15119]
GtoPdb In vitro functional assay - 7.08 pIC50 84 nM IC50 Oncotarget (2014) 5: 12862-76 [PMID:25404640]
pyruvate dehydrogenase kinase 3 in Human [GtoPdb: 2143] [UniProtKB: Q15120]
GtoPdb In vitro functional assay - 7.4 pIC50 40 nM IC50 Oncotarget (2014) 5: 12862-76 [PMID:25404640]
pyruvate dehydrogenase kinase 4 in Human [GtoPdb: 2144] [UniProtKB: Q16654]
GtoPdb In vitro functional assay - 7.04 pIC50 91 nM IC50 Oncotarget (2014) 5: 12862-76 [PMID:25404640]
pyruvate dehydrogenase kinase 1 in Human [GtoPdb: 2915] [UniProtKB: Q15118]
GtoPdb In vitro functional assay - 7.46 pIC50 35 nM IC50 Oncotarget (2014) 5: 12862-76 [PMID:25404640]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.