3M-002 [Ligand Id: 9270] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL512901 (CL-075) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1] | ||||||||
| ChEMBL | Agonist activity at TLR7 in human cryopreserved PBMC assessed as induction of IFNalpha production measured after 24 hrs | B | 4.74 | pEC50 | 18000 | nM | EC50 | J Med Chem (2020) 63: 10188-10203 [PMID:32407112] |
| TLR8/Toll-like receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5805] [GtoPdb: 1758] [UniProtKB: Q9NR97] | ||||||||
| ChEMBL | Agonist activity at TLR8 in human cryopreserved PBMC assessed as inhibition of IL-12p40 production measured after 24 hrs | B | 5.31 | pEC50 | 4900 | nM | EC50 | J Med Chem (2020) 63: 10188-10203 [PMID:32407112] |
| ChEMBL | Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay | F | 5.88 | pEC50 | 1320 | nM | EC50 | J Med Chem (2012) 55: 8137-8151 [PMID:22924757] |
| GtoPdb | Assessed as ability to activate NF-κB in HEK293 cells expressing human TLR8. | - | 5.88 | pEC50 | 1320 | nM | EC50 | J Med Chem (2012) 55: 8137-51 [PMID:22924757] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
