ChEMBL ligand: CHEMBL512901 (CL-075)
TLR7/Toll-like receptor 7 in Human [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1] There should be some charts here, you may need to enable JavaScript!
TLR8/Toll-like receptor 8 in Human [ChEMBL: CHEMBL5805] [GtoPdb: 1758] [UniProtKB: Q9NR97] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1]
ChEMBL	Agonist activity at TLR7 in human cryopreserved PBMC assessed as induction of IFNalpha production measured after 24 hrs	B	4.74	pEC50	18000	nM	EC50	J Med Chem (2020) 63: 10188-10203 [PMID:32407112]
ChEMBL	Agonist activity at human TLR7 in HEK-Blue hTLR7 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay	B	5.26	pEC50	5480	nM	EC50	RSC Med Chem (2021) 12: 1065-1120 [PMID:34355178]
TLR8/Toll-like receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5805] [GtoPdb: 1758] [UniProtKB: Q9NR97]
ChEMBL	Agonist activity at TLR8 in human cryopreserved PBMC assessed as inhibition of IL-12p40 production measured after 24 hrs	B	5.31	pEC50	4900	nM	EC50	J Med Chem (2020) 63: 10188-10203 [PMID:32407112]
ChEMBL	Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay	F	5.88	pEC50	1320	nM	EC50	J Med Chem (2012) 55: 8137-8151 [PMID:22924757]
ChEMBL	Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay	B	5.88	pEC50	1320	nM	EC50	RSC Med Chem (2021) 12: 1065-1120 [PMID:34355178]
GtoPdb	Assessed as ability to activate NF-κB in HEK293 cells expressing human TLR8.	-	5.88	pEC50	1320	nM	EC50	J Med Chem (2012) 55: 8137-51 [PMID:22924757]
ChEMBL	Agonist activity in TLR8 (unknown origin) expressed in HEK293 cells assessed as induction of NF-kappa activation	B	6.1	pEC50	800	nM	EC50	Eur J Med Chem (2020) 193: 112238-112238 [PMID:32203790]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]