ChEMBL ligand: CHEMBL2057915
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Mouse [ChEMBL: CHEMBL3259478] [GtoPdb: 1948] [UniProtKB: P35991] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL	Inhibition of BTK (unknown origin) by Lanthascreen assay	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2016) 26: 575-579 [PMID:26675441]
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1333-7 [PMID:25701252]
ChEMBL	Inhibition of BTK (unknown origin) by Lanthascreen method	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1333-1337 [PMID:25701252]
ChEMBL	Inhibition of human BTK by enzymatic assay	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2012) 55: 4539-4550 [PMID:22394077]
ChEMBL	Inhibition of BTK in human whole blood B-cells assessed as inhibition of both anti-IgD-stimulated CD69 expression	B	6.42	pEC50	380	nM	EC50	Bioorg Med Chem Lett (2015) 25: 1333-1337 [PMID:25701252]
ChEMBL	Inhibition of BTK in human whole blood basophils assessed as inhibition of both anti-IgE-stimulated CD63 expression	B	6.46	pEC50	350	nM	EC50	Bioorg Med Chem Lett (2015) 25: 1333-1337 [PMID:25701252]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259478] [GtoPdb: 1948] [UniProtKB: P35991]
ChEMBL	Inhibition of BTK-mediated CD86 surface expression in Balb/c mouse splenocytes preincubated for 60 mins before F(ab')2 anti-mouse IgM measured after 24 hrs by flow cytometry	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1333-1337 [PMID:25701252]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]