L779450 [Ligand Id: 9129] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL373011 (L-779450) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Binding affinity at bRaf kinase in fluorescent ligand displacement assay | B | 8.62 | pKd | 2.4 | nM | Kd | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Binding affinity to B-Raf by fluorescene ligand binding assay | B | 8.62 | pKd | 2.4 | nM | Kd | Bioorg Med Chem Lett (2008) 18: 4373-4376 [PMID:18621524] |
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-81 [PMID:16260133] |
| ChEMBL | Inhibition bRaf kinase activity | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Inhibition of B-Raf V600E mutant | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1248-1252 [PMID:21211972] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2346-50 [PMID:18346893] |
| ChEMBL | Inhibition of Raf1 kinase | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2346-2350 [PMID:18346893] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
