[3H]JB-93182 [Ligand Id: 908] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14557
  • Cholecystokinin A receptor in Guinea pig [ChEMBL: CHEMBL3501] [UniProtKB: Q63931]
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  • CCK2 receptor/Cholecystokinin B receptor in Mouse [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
  • CCK2 receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931]
ChEMBL Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells B 5.4 pKi 3981.07 nM Ki J Med Chem (2008) 51: 565-573 [PMID:18201065]
ChEMBL In vitro inhibitory activity against Cholecystokinin type A receptor using [125I]BH-CCK-8S as radioligand in guinea pig pancreatic cells B 5.44 pKi 3630.78 nM Ki J Med Chem (1996) 39: 1806-1815 [PMID:8627604]
CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
ChEMBL Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates B 8.95 pKi 1.12 nM Ki J Med Chem (2000) 43: 3518-3529 [PMID:11000006]
ChEMBL In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes B 8.96 pKi 1.1 nM Ki J Med Chem (1996) 39: 1806-1815 [PMID:8627604]
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
GtoPdb - - 9.5 pKd - - - Br J Pharmacol (1999) 126: 1504-12 [PMID:10217546]
ChEMBL Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand. B 7.63 pKi 23.44 nM Ki Bioorg Med Chem Lett (1996) 6: 1171-1174

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]