JNJ40355003 [Ligand Id: 9050] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2164602 (JNJ-40355003) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385] |
| ChEMBL | Inhibition of human FAAH after 1 hr | B | 8.85 | pIC50 | 1.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
| ChEMBL | Inhibition of human FAAH preincubated for 60 mins | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7357-7362 [PMID:23141911] |
| ChEMBL | Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3109-3114 [PMID:27189675] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385] |
| ChEMBL | Inhibition of rat FAAH after 1 hr | B | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
| ChEMBL | Inhibition of rat FAAH preincubated for 60 mins | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7357-7362 [PMID:23141911] |
| ChEMBL | Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3109-3114 [PMID:27189675] |
| Fatty acid amide hydrolase-2/Fatty-acid amide hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628475] [GtoPdb: 1401] [UniProtKB: Q6GMR7] | ||||||||
| ChEMBL | Inhibition of FAAH2 | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
