bimosiamose [Ligand Id: 9049] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1215923 (Bimosiamosa, Bimosiamose, TBC-1269)
Created with Highcharts 10.3.3ValuesChart context menuP-selectinpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • P-selectin glycoprotein ligand 1 in Human [ChEMBL: CHEMBL4183] [UniProtKB: Q14242]
Created with Highcharts 10.3.3ValuesChart context menuP-selectin glycoprotein ligand 1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109]
ChEMBL Inhibition of human P-selectin after 2 hrs B 4.02 pIC50 95000 nM IC50 J Med Chem (2007) 50: 1101-1115 [PMID:17302397]
GtoPdb Inhibition of P-selectin binding in an HL-60 cellular assay. - 4.15 pIC50 70000 nM IC50 J Med Chem (1998) 41: 1099-111 [PMID:9544210]
ChEMBL Inhibition of P-selectin in human HL-60 cells B 4.15 pIC50 70000 nM IC50 J Med Chem (2010) 53: 6003-6017 [PMID:20718494]
P-selectin glycoprotein ligand 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4183] [UniProtKB: Q14242]
ChEMBL Inhibition of P-selectin-mediated adhesion of HL60 cells B 4.15 pIC50 70000 nM IC50 J Med Chem (2007) 50: 21-39 [PMID:17201408]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]