PD-140548 [Ligand Id: 904] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL356898 (PD-140548) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas. | B | 7.59 | pIC50 | 25.5 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 2805-2810 |
| ChEMBL | Inhibition of [3H]propionyl-CCK-8 binding to rat pancreas cholecystokinin-A (CCK-A) receptor | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454] |
| ChEMBL | Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| GtoPdb | - | - | 8.6 | pIC50 | 2.5 | nM | IC50 | Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse | B | 6.61 | pKi | 245.47 | nM | Ki | J Med Chem (1992) 35: 1572-1577 [PMID:1578483] |
| ChEMBL | Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor | B | 6.59 | pIC50 | 259 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 43-48 [PMID:9990454] |
| ChEMBL | Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 6.59 | pIC50 | 259 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| ChEMBL | In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 2805-2810 |
| CCK2 receptor in Rat [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | - | - | - | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
