ChEMBL ligand: CHEMBL2326089
Arginase I/Arginase-1 in Human [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089] There should be some charts here, you may need to enable JavaScript!
Arginase II/Arginase-2, mitochondrial in Human [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089]
ChEMBL	Inhibition of human arginase 1 transfected in CHO cells assessed as inhibition of urea formation after 24 hrs by spectrophotometric analysis	B	5.52	pIC50	3000	nM	IC50	J Med Chem (2013) 56: 2568-2580 [PMID:23472952]
ChEMBL	Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric assay	B	6.29	pIC50	509	nM	IC50	Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287]
GtoPdb	-	-	6.65	pIC50	223	nM	IC50	J Med Chem (2013) 56: 2568-80 [PMID:23472952]
ChEMBL	Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	B	6.65	pIC50	223	nM	IC50	J Med Chem (2013) 56: 2568-2580 [PMID:23472952]
ChEMBL	Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay	B	7.74	pIC50	18	nM	IC50	ACS Med Chem Lett (2020) 11: 582-588 [PMID:32292567]
Arginase II/Arginase-2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540]
GtoPdb	-	-	6.29	pIC50	509	nM	IC50	J Med Chem (2013) 56: 2568-80 [PMID:23472952]
ChEMBL	Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	B	6.29	pIC50	509	nM	IC50	J Med Chem (2013) 56: 2568-2580 [PMID:23472952]
ChEMBL	Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric assay	B	6.29	pIC50	509	nM	IC50	Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]