ChEMBL ligand: CHEMBL3183531
lysine demethylase 5B/Lysine-specific demethylase 5B in Human [ChEMBL: CHEMBL3774295] [GtoPdb: 2681] [UniProtKB: Q9UGL1] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 6A/Lysine-specific demethylase 6A in Human [ChEMBL: CHEMBL2069164] [GtoPdb: 2684] [UniProtKB: O15550] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 6B/Lysine-specific demethylase 6B in Human [ChEMBL: CHEMBL1938211] [GtoPdb: 2685] [UniProtKB: O15054] There should be some charts here, you may need to enable JavaScript!
Methylcytosine dioxygenase TET1 in Human [ChEMBL: CHEMBL4523402] [UniProtKB: Q8NFU7] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine demethylase 5B/Lysine-specific demethylase 5B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3774295] [GtoPdb: 2681] [UniProtKB: Q9UGL1]
GtoPdb	-	-	5.01	pIC50	9700	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
ChEMBL	Inhibition of KDM5B (unknown origin)	B	5.01	pIC50	9700	nM	IC50	Eur J Med Chem (2020) 208: 112760-112760 [PMID:32883639]
lysine demethylase 6A/Lysine-specific demethylase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069164] [GtoPdb: 2684] [UniProtKB: O15550]
ChEMBL	Affinity Phenotypic Cellular interaction (Inhibition of TNF release (in LPS stimulated human macrophages derived from PBMC)) EUB0000217b KDM6A/UTX	F	5.05	pIC50	9000	nM	IC50	Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomics Library wave 3
GtoPdb	-	-	5.18	pIC50	6600	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
ChEMBL	Affinity Biochemical interaction (AlphaLISA based assay) EUB0000217b KDM6A/UTX	B	5.18	pIC50	6600	nM	IC50	Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3
lysine demethylase 6B/Lysine-specific demethylase 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938211] [GtoPdb: 2685] [UniProtKB: O15054]
ChEMBL	Inhibition of JMJD3 (unknown origin) by Alphascreen assay	B	5.07	pIC50	8600	nM	IC50	Bioorg Med Chem Lett (2023) 94: 129466-129466 [PMID:37660833]
GtoPdb	-	-	5.07	pIC50	8600	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
Methylcytosine dioxygenase TET1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523402] [UniProtKB: Q8NFU7]
ChEMBL	Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in human U2OS cells assessed as reduction in 5-hydroxymethylcytosine level incubated for 24 hrs by immunofluorescence analysis	B	4.8	pEC50	16000	nM	EC50	J Med Chem (2024) 67: 4525-4540 [PMID:38294854]
ChEMBL	Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in human U2OS cells assessed as reduction in 5-hydroxymethylcytosine level incubated for 24 hrs by immunofluorescence analysis	B	4.8	pEC50	15848.93	nM	EC50	J Med Chem (2024) 67: 4525-4540 [PMID:38294854]
lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229]
GtoPdb	-	-	4.82	pIC50	15000	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]