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ChEMBL ligand: CHEMBL255738 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Mixed-type inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate | B | 6.33 | pKi | 470 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate | B | 6.35 | pKi | 450 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate | B | 6.4 | pKi | 400 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate | B | 6.92 | pKi | 120 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate | B | 7 | pKi | 100 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of human recombinant Abl | B | 7.36 | pKi | 44 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752] |
GtoPdb | - | - | 7.36 | pKi | 44 | nM | Ki |
Bioorg Med Chem Lett (2008) 18: 1207-11 [PMID:18078752]; Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate | B | 6.26 | pKi | 550 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using KVEKIGEGTYGVVYK as substrate | B | 6.26 | pKi | 550 | nM | Ki | Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394] |
ChEMBL | Inhibition of recombinant human c-Src | B | 6.45 | pKi | 354 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]